Effect of Ala-2-D-Trp-8-D-Cys-14-Somatostatin on the Arginine Induced Release of Insulin, Gh and Glucagon in Normal Men

David Gonzalez-Barcena, Fernando Mendoza, Roberto Medina, David H. Coy, William A. Murphy, Andrew V. Schally

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The effects of several doses of somatostatin (SS) and the analog Ala-2-D-Trp-8-D-Cys-14-SS on the arginine-induced release of insulin, glucagon, and GH were compared in a group of normal human subjects. Somatostatin suppressed the release of insulin, glucagon and GH when administered in a dose of 100 ug/hr. The same dose of Ala-2-D-Trp-8-D-Cys-14-SS inhibited GH and glucagon release, but although insulin levels were decreased about 24%, this inhibition was not significant statistically. Higher doses of Ala-2-D-Trp-8-D-Cys-14-SS (300 ug/hr) induced a partial inhibition of insulin secretion and completely blocked GH release. These results indicate that in humans this analog is a less potent inhibitor of insulin release than somatostatin.

Original languageEnglish (US)
Pages (from-to)39-48
Number of pages10
JournalEndocrine Research
Volume10
Issue number1
DOIs
StatePublished - Jan 1984
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Effect of Ala-2-D-Trp-8-D-Cys-14-Somatostatin on the Arginine Induced Release of Insulin, Gh and Glucagon in Normal Men'. Together they form a unique fingerprint.

  • Cite this