Effect of Ala-2-D-Trp-8-D-Cys-14-Somatostatin on the Arginine Induced Release of Insulin, Gh and Glucagon in Normal Men

David Gonzalez-Barcena, Fernando Mendoza, Roberto Medina, David H. Coy, William A. Murphy, Andrew V Schally

Research output: Contribution to journalArticle

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Abstract

The effects of several doses of somatostatin (SS) and the analog Ala-2-D-Trp-8-D-Cys-14-SS on the arginine-induced release of insulin, glucagon, and GH were compared in a group of normal human subjects. Somatostatin suppressed the release of insulin, glucagon and GH when administered in a dose of 100 ug/hr. The same dose of Ala-2-D-Trp-8-D-Cys-14-SS inhibited GH and glucagon release, but although insulin levels were decreased about 24%, this inhibition was not significant statistically. Higher doses of Ala-2-D-Trp-8-D-Cys-14-SS (300 ug/hr) induced a partial inhibition of insulin secretion and completely blocked GH release. These results indicate that in humans this analog is a less potent inhibitor of insulin release than somatostatin.

Original languageEnglish (US)
Pages (from-to)39-48
Number of pages10
JournalEndocrine Research
Volume10
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

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Glucagon
Arginine
Insulin
Somatostatin
Trp(8)-Cys(14)-somatostatin

ASJC Scopus subject areas

  • Endocrinology

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Effect of Ala-2-D-Trp-8-D-Cys-14-Somatostatin on the Arginine Induced Release of Insulin, Gh and Glucagon in Normal Men. / Gonzalez-Barcena, David; Mendoza, Fernando; Medina, Roberto; Coy, David H.; Murphy, William A.; Schally, Andrew V.

In: Endocrine Research, Vol. 10, No. 1, 1984, p. 39-48.

Research output: Contribution to journalArticle

Gonzalez-Barcena, David ; Mendoza, Fernando ; Medina, Roberto ; Coy, David H. ; Murphy, William A. ; Schally, Andrew V. / Effect of Ala-2-D-Trp-8-D-Cys-14-Somatostatin on the Arginine Induced Release of Insulin, Gh and Glucagon in Normal Men. In: Endocrine Research. 1984 ; Vol. 10, No. 1. pp. 39-48.
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