Effect of adriamycin and analogs on the nuclear fluorescence of propidium iodide-stained cells

A. Krishan, R. N. Ganapathi, M. Israel

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37 Scopus citations

Abstract

Adriamycin (ADR) and N-trifluoroacetyladriamycin-14-valerate, respectively, inhibit and enhance the nuclear fluorescence of cells stained with propidium iodide for DNA per cell estimation by flow cytometry. In cells incubated with ADR, the reduction in fluorescence is gradually manifested due to the slow intracellular drug transport. In contrast the effect of N-trifluoroacetyladriamycin-14-valerate on propidium iodide nuclear fluorescence is seen within 5 min of incubation. The effect of ADR on propidium iodide nuclear fluorescence could be detected in vivo even after 24 hr of ADR administration.

Original languageEnglish
Pages (from-to)3656-3662
Number of pages7
JournalCancer Research
Volume38
Issue number11 I
StatePublished - Dec 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Krishan, A., Ganapathi, R. N., & Israel, M. (1978). Effect of adriamycin and analogs on the nuclear fluorescence of propidium iodide-stained cells. Cancer Research, 38(11 I), 3656-3662.