Effect of acute hyperinsulinemia on ventricular repolarization in uncomplicated obesity

Gianluca Iacobellis, Mario Curione, Simonetta Di Bona, Maria Cristina Ribaudo, Alessandra Zappaterreno, Elio Vecci, Umberto Di Mario, Frida Leonetti

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Acute hyperinsulinemia has been shown to increase QTc interval in lean subjects, but data on obese subjects are still unclear. Aim of this study was to evaluate the effect of acute hyperinsulinemia on QTc interval and QTc dispersion in uncomplicated obesity. Methods: We calculated QTc duration and QTc dispersion in 30 uncomplicated obese subjects (mean age 32.2±7, BMI 36.7±9.4 kg/m2) by measurements of 12-lead ECG recording during a euglycemic hyperinsulinemic clamp. Results: Insulin infusion during the clamp did not significantly modify QTc interval and QTc dispersion in uncomplicated obese subjects (401.5±29.2 vs. 413.7±30.5; 35.4±10.5 vs. 38.7±14.5, respectively). Conclusions: Acute hyperinsulinemia seems to no significantly affect ventricular repolarization in uncomplicated obesity. Insulin resistance and the absence of diabetes and hypertension could explain, at least in part, this finding.

Original languageEnglish (US)
Pages (from-to)161-163
Number of pages3
JournalInternational Journal of Cardiology
Volume99
Issue number1
DOIs
StatePublished - Mar 10 2005
Externally publishedYes

Keywords

  • Insulin
  • QTc interval
  • Uncomplicated obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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