Effect of ACTH and cAMP on human adrenocortical growth and function in vitro

Bernard A. Roos

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Viable adrenal cells have been isolated from human fetuses and have been maintained in monolayer cell culture. In response to several days of ACTH treatment these cultures exhibit increasing capacity for corticosteroidogenesis. In the presence of a low-serum medium, this ACTH treatment also results in increased growth of these cultures. cAMP stimulates steroidogenesis but not growth, while fetal calf serum stimulates growth but not steroidogenesis.

Original languageEnglish (US)
Pages (from-to)685-690
Number of pages6
JournalEndocrinology
Volume94
Issue number3
DOIs
StatePublished - Mar 1974

ASJC Scopus subject areas

  • Endocrinology

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