Effect of acetazolamide on ocular hemodynamics in pseudotumor cerebri associated with inflammatory bowel disease

Max A. Villain, Georges P. Pageaux, Michel Veyrac, Bernard Arnaud, Alon Harris, David Greenfield

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

PURPOSE: To describe the hemodynamic effect of oral acetazolamide administration on ocular perfusion in a patient with pseudotumor cerebri associated with Crohn disease. DESIGN: Interventional case report. METHODS: A 20-year-old woman with a 5-year history of Crohn disease presented with a 2-week history of headache and blurred vision in both eyes. Ophthalmologic examination was normal. Fluorescein angiography showed a profound delay in retinal and choroidal perfusion. Lumbar puncture showed an opening pressure of 320 mm water. Therapy was initiated with oral acetazolamide 750 mg per day. RESULTS: A subjective improvement of symptoms was noted over 4 days. Repeat fluorescein angiography showed resolution of the ocular perfusion deficit. No recurrent symptoms were noted 19 months after cessation of therapy. CONCLUSIONS: Crohn disease may present with pseudotumor cerebri and severe ocular perfusion deficits that are reversible with oral acetazolamide therapy.

Original languageEnglish
Pages (from-to)778-780
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume134
Issue number5
DOIs
StatePublished - Nov 1 2002

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Pseudotumor Cerebri
Acetazolamide
Inflammatory Bowel Diseases
Perfusion
Hemodynamics
Crohn Disease
Fluorescein Angiography
Spinal Puncture
Headache
Oral Administration
Therapeutics
Pressure
Water

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effect of acetazolamide on ocular hemodynamics in pseudotumor cerebri associated with inflammatory bowel disease. / Villain, Max A.; Pageaux, Georges P.; Veyrac, Michel; Arnaud, Bernard; Harris, Alon; Greenfield, David.

In: American Journal of Ophthalmology, Vol. 134, No. 5, 01.11.2002, p. 778-780.

Research output: Contribution to journalArticle

Villain, Max A. ; Pageaux, Georges P. ; Veyrac, Michel ; Arnaud, Bernard ; Harris, Alon ; Greenfield, David. / Effect of acetazolamide on ocular hemodynamics in pseudotumor cerebri associated with inflammatory bowel disease. In: American Journal of Ophthalmology. 2002 ; Vol. 134, No. 5. pp. 778-780.
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AU - Harris, Alon

AU - Greenfield, David

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