Effect of a Powerful Antagonist of LH-RH on Testicular Function in Prepubertal Male Rats

L. Debeljuk; V. M. Maines; D. H. Coy; A. V. Schally

doi:10.3109/01485018308987466

Effect of a Powerful Antagonist of LH-RH on Testicular Function in Prepubertal Male Rats

L. Debeljuk, V. M. Maines, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The effects of N-Ac-D-p-F-Phe¹,D-p-Cl-Phe²,D-Trp^3,6,D-Ala¹⁰-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.

Original language	English (US)
Pages (from-to)	89-93
Number of pages	5
Journal	Archives of Andrology
Volume	11
Issue number	1
DOIs	https://doi.org/10.3109/01485018308987466
State	Published - Jan 1983
Externally published	Yes

Keywords

Antagonists
LH-RH
Rat
Testes

ASJC Scopus subject areas

Endocrinology

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title = "Effect of a Powerful Antagonist of LH-RH on Testicular Function in Prepubertal Male Rats",

abstract = "The effects of N-Ac-D-p-F-Phe1,D-p-Cl-Phe2,D-Trp3,6,D-Ala10-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.",

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AB - The effects of N-Ac-D-p-F-Phe1,D-p-Cl-Phe2,D-Trp3,6,D-Ala10-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.

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