Abstract
The effects of N-Ac-D-p-F-Phe1,D-p-Cl-Phe2,D-Trp3,6,D-Ala10-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 89-93 |
| Number of pages | 5 |
| Journal | Archives of Andrology |
| Volume | 11 |
| Issue number | 1 |
| State | Published - Jan 1 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Effect of a powerful antagonist of LH-RH on testicular function in prepubertal male rats. / Debeljuk, L.; Maines, V. M.; Coy, D. H.; Schally, Andrew V.
In: Archives of Andrology, Vol. 11, No. 1, 01.01.1983, p. 89-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of a powerful antagonist of LH-RH on testicular function in prepubertal male rats
AU - Debeljuk, L.
AU - Maines, V. M.
AU - Coy, D. H.
AU - Schally, Andrew V
PY - 1983/1/1
Y1 - 1983/1/1
N2 - The effects of N-Ac-D-p-F-Phe1,D-p-Cl-Phe2,D-Trp3,6,D-Ala10-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.
AB - The effects of N-Ac-D-p-F-Phe1,D-p-Cl-Phe2,D-Trp3,6,D-Ala10-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020563049&partnerID=8YFLogxK
M3 - Article
C2 - 6414396
AN - SCOPUS:0020563049
VL - 11
SP - 89
EP - 93
JO - Systems Biology in Reproductive Medicine
JF - Systems Biology in Reproductive Medicine
SN - 1939-6376
IS - 1
ER -