Effect of a Powerful Antagonist of LH-RH on Testicular Function in Prepubertal Male Rats

L. Debeljuk, V. M. Maines, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of N-Ac-D-p-F-Phe1,D-p-Cl-Phe2,D-Trp3,6,D-Ala10-LH-RH, a new antagonistic analog of LH-RH, were tested on the testicular function and serum FSH and LH levels in immature male rats. Prolonged administration of this analog to prepubertal male rats resulted in lower testicular and seminal vesicle weights as compared with control rats treated with the vehicle only. Spermatogenesis was markedly delayed in rats injected with the analog. Serum FSH and LH levels were significantly lower in the analog-treated rats as compared to the controls. These data show that LH-RH antagonists may be useful for inhibition of spermatogenesis.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalArchives of Andrology
Volume11
Issue number1
DOIs
StatePublished - Jan 1983
Externally publishedYes

Keywords

  • Antagonists
  • LH-RH
  • Rat
  • Testes

ASJC Scopus subject areas

  • Endocrinology

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