Effect of 1,2-dimethyl-3-hydroxypyridin-4-one (L1) on zinc absorption

Nejat Akar; Mustafa Tekin; Zümrüt Uysal; Orner Uzunali

doi:10.1002/(SICI)1520-670X(1998)11:1<5::AID-JTRA2>3.0.CO;2-C

Effect of 1,2-dimethyl-3-hydroxypyridin-4-one (L1) on zinc absorption

Nejat Akar, Mustafa Tekin, Zümrüt Uysal, Orner Uzunali

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The aim of the study was to determine the effect of L1 on zinc absorption in healthy individuals. Ten healthy volunteer individuals were included. Oral zinc tolerance test was performed first with 120 mg ZnSO₄·7H₂O (22.5 mg elementary zinc) and then with zinc sulfate and deferiprone (L1) at a dose of 500 mg. Plasma and urine zinc concentrations were assessed by an atomic absorption spectrophotomer. When zinc profile values during the OZTT were compared, there was only a significant increase during the 3rd hour (147 ± 6.5 μg/dl vs. 166.4 ± 13.8 μg/dl) in the zinc sulfate + L1 trial. However AUC4 values for both tests were 2.623 ± 0.193 and 2.874 ± 0.247, respectively. The difference was not significant (P > .05). Our data revealed that L1 does not have a negative effect on zinc absorption. So, we concluded that L1 and zinc can be given together orally.

Original language	English (US)
Pages (from-to)	5-9
Number of pages	5
Journal	Journal of Trace Elements in Experimental Medicine
Volume	11
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1520-670X(1998)11:1<5::AID-JTRA2>3.0.CO;2-C
State	Published - May 1 1998
Externally published	Yes

Keywords

Iron
Thalassemia
Zinc

ASJC Scopus subject areas

Biochemistry

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10.1002/(SICI)1520-670X(1998)11:1<5::AID-JTRA2>3.0.CO;2-C

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title = "Effect of 1,2-dimethyl-3-hydroxypyridin-4-one (L1) on zinc absorption",

abstract = "The aim of the study was to determine the effect of L1 on zinc absorption in healthy individuals. Ten healthy volunteer individuals were included. Oral zinc tolerance test was performed first with 120 mg ZnSO4·7H2O (22.5 mg elementary zinc) and then with zinc sulfate and deferiprone (L1) at a dose of 500 mg. Plasma and urine zinc concentrations were assessed by an atomic absorption spectrophotomer. When zinc profile values during the OZTT were compared, there was only a significant increase during the 3rd hour (147 ± 6.5 μg/dl vs. 166.4 ± 13.8 μg/dl) in the zinc sulfate + L1 trial. However AUC4 values for both tests were 2.623 ± 0.193 and 2.874 ± 0.247, respectively. The difference was not significant (P > .05). Our data revealed that L1 does not have a negative effect on zinc absorption. So, we concluded that L1 and zinc can be given together orally.",

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author = "Nejat Akar and Mustafa Tekin and Z{\"u}mr{\"u}t Uysal and Orner Uzunali",

year = "1998",

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AU - Akar, Nejat

AU - Tekin, Mustafa

AU - Uysal, Zümrüt

AU - Uzunali, Orner

PY - 1998/5/1

Y1 - 1998/5/1

N2 - The aim of the study was to determine the effect of L1 on zinc absorption in healthy individuals. Ten healthy volunteer individuals were included. Oral zinc tolerance test was performed first with 120 mg ZnSO4·7H2O (22.5 mg elementary zinc) and then with zinc sulfate and deferiprone (L1) at a dose of 500 mg. Plasma and urine zinc concentrations were assessed by an atomic absorption spectrophotomer. When zinc profile values during the OZTT were compared, there was only a significant increase during the 3rd hour (147 ± 6.5 μg/dl vs. 166.4 ± 13.8 μg/dl) in the zinc sulfate + L1 trial. However AUC4 values for both tests were 2.623 ± 0.193 and 2.874 ± 0.247, respectively. The difference was not significant (P > .05). Our data revealed that L1 does not have a negative effect on zinc absorption. So, we concluded that L1 and zinc can be given together orally.

AB - The aim of the study was to determine the effect of L1 on zinc absorption in healthy individuals. Ten healthy volunteer individuals were included. Oral zinc tolerance test was performed first with 120 mg ZnSO4·7H2O (22.5 mg elementary zinc) and then with zinc sulfate and deferiprone (L1) at a dose of 500 mg. Plasma and urine zinc concentrations were assessed by an atomic absorption spectrophotomer. When zinc profile values during the OZTT were compared, there was only a significant increase during the 3rd hour (147 ± 6.5 μg/dl vs. 166.4 ± 13.8 μg/dl) in the zinc sulfate + L1 trial. However AUC4 values for both tests were 2.623 ± 0.193 and 2.874 ± 0.247, respectively. The difference was not significant (P > .05). Our data revealed that L1 does not have a negative effect on zinc absorption. So, we concluded that L1 and zinc can be given together orally.

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KW - Thalassemia

KW - Zinc

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Effect of 1,2-dimethyl-3-hydroxypyridin-4-one (L1) on zinc absorption

Abstract

Keywords

ASJC Scopus subject areas

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