Economic Burden of Non-Infectious Inflammatory Eye Disease (NIIED) in a Commercially-Insured Population in the United States

Thomas A Albini, J. Bradford Rice, Alan G. White, Michaela Johnson, Julie Reiff, Antonio Flavio Lima, Laura Bartels-Peculis, Gosia Ciepielewska, Winnie W. Nelson

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Purpose: To assess the economic burden of non-infectious inflammatory eyedisease (NIIED) in a commercially-insured population in the United States Methods: Adult patients with a NIIED diagnosis between 2006 and 2015 were selected from a de-identified, privately insured claims database and were matched 1:1 to a non-NIIED control. Ophthalmologic complications, direct healthcare resource use and costs, and indirect work loss (from the payer perspective) were calculated for a 12-month period and compared across the 2 cohorts. Results: Among the 14 876 matched pairs, NIIED patients were significantly more likely than controls to experience ocular complications, including glaucoma and cataracts (p < 0.001). NIIED patients had significantly higher healthcare resource utilization and costs compared with matched controls (relative difference 40%, p < 0.001). NIIED patients missed 12.2 days of work ($2925 annual work-loss costs), 46% more than non-NIIED patients (p < 0.001). Conclusion: NIIED imposes a significant clinical and economic burden, suggesting an unmet need for expanded access to alternative treatment options.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
StatePublished - Jan 1 2019



  • economic burden
  • healthcare resource use
  • indirect work loss
  • non-infectious inflammatory eye disease
  • opthalmologic complications

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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