Echogenic endometrial fluid collection in postmenopausal women is a significant risk factor for disease

Peter Takacs, Timothy De Santis, M. Catherine Nicholas, Usha Verma, Richard Strassberg, Lunthita Duthely

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. The purpose of this study was to assess postmenopausal women with endometrial fluid collection and the risk of significant endometrial or cervical disease. Methods. A retrospective chart review was conducted of 343 postmenopausal women with endometrial fluid collection on pelvic sonography. Medical records were reviewed to identify women who underwent an evaluation of the endometrium with endometrial biopsy, hysteroscopy, or hysterectomy after the sonographic examination. Clinical and sonographic characteristics were compared between women with diagnoses of cervical or endometrial cancer or hyperplasia (nonbenign group) and women with benign conditions (benign group). Results. The endometrium was significantly thicker in the nonbenign group compared with the benign group (mean ± SD, 9.9 ± 7.4 versus 5.9 ± 4.1 mm; P = .016). None of the patients with adenocarcinoma of the endometrium had endometrial thickness of 3 mm or less, but 2 with endocervical cancer did. Echogenic fluid in the endometrial cavity was significantly more likely to be found in the nonbenign group compared with the benign group (45.8% versus 4.8%; P < .01). Multivariate logistic regression analysis revealed that echogenic fluid in the endometrial cavity was the only significant risk factor for nonbenign conditions (odds ratio, 10.94; 95% confidence interval, 2.67-44.84; P < .01). Conclusions. Postmenopausal women with endometrial fluid collection on sonography should undergo endometrial sampling if the endometrial lining is thicker than 3 mm or the endometrial fluid is echogenic. If the lining is 3 mm or less and the endometrial fluid is clear, endometrial sampling is not necessary, but we recommend endocervical sampling to rule out endocervical cancer.

Original languageEnglish
Pages (from-to)1477-1481
Number of pages5
JournalJournal of Ultrasound in Medicine
Volume24
Issue number11
StatePublished - Nov 1 2005

Fingerprint

fluids
Endometrium
cancer
sampling
linings
Ultrasonography
Endometrial Hyperplasia
Hysteroscopy
cavities
Endometrial Neoplasms
Hysterectomy
Uterine Cervical Neoplasms
logistics
charts
Medical Records
Neoplasms
Adenocarcinoma
Logistic Models
Odds Ratio
Regression Analysis

Keywords

  • Echogenicity
  • Edometrial fluid
  • Endometrial cancer
  • Menopause

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Echogenic endometrial fluid collection in postmenopausal women is a significant risk factor for disease. / Takacs, Peter; De Santis, Timothy; Nicholas, M. Catherine; Verma, Usha; Strassberg, Richard; Duthely, Lunthita.

In: Journal of Ultrasound in Medicine, Vol. 24, No. 11, 01.11.2005, p. 1477-1481.

Research output: Contribution to journalArticle

Takacs, Peter ; De Santis, Timothy ; Nicholas, M. Catherine ; Verma, Usha ; Strassberg, Richard ; Duthely, Lunthita. / Echogenic endometrial fluid collection in postmenopausal women is a significant risk factor for disease. In: Journal of Ultrasound in Medicine. 2005 ; Vol. 24, No. 11. pp. 1477-1481.
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abstract = "Objective. The purpose of this study was to assess postmenopausal women with endometrial fluid collection and the risk of significant endometrial or cervical disease. Methods. A retrospective chart review was conducted of 343 postmenopausal women with endometrial fluid collection on pelvic sonography. Medical records were reviewed to identify women who underwent an evaluation of the endometrium with endometrial biopsy, hysteroscopy, or hysterectomy after the sonographic examination. Clinical and sonographic characteristics were compared between women with diagnoses of cervical or endometrial cancer or hyperplasia (nonbenign group) and women with benign conditions (benign group). Results. The endometrium was significantly thicker in the nonbenign group compared with the benign group (mean ± SD, 9.9 ± 7.4 versus 5.9 ± 4.1 mm; P = .016). None of the patients with adenocarcinoma of the endometrium had endometrial thickness of 3 mm or less, but 2 with endocervical cancer did. Echogenic fluid in the endometrial cavity was significantly more likely to be found in the nonbenign group compared with the benign group (45.8{\%} versus 4.8{\%}; P < .01). Multivariate logistic regression analysis revealed that echogenic fluid in the endometrial cavity was the only significant risk factor for nonbenign conditions (odds ratio, 10.94; 95{\%} confidence interval, 2.67-44.84; P < .01). Conclusions. Postmenopausal women with endometrial fluid collection on sonography should undergo endometrial sampling if the endometrial lining is thicker than 3 mm or the endometrial fluid is echogenic. If the lining is 3 mm or less and the endometrial fluid is clear, endometrial sampling is not necessary, but we recommend endocervical sampling to rule out endocervical cancer.",
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N2 - Objective. The purpose of this study was to assess postmenopausal women with endometrial fluid collection and the risk of significant endometrial or cervical disease. Methods. A retrospective chart review was conducted of 343 postmenopausal women with endometrial fluid collection on pelvic sonography. Medical records were reviewed to identify women who underwent an evaluation of the endometrium with endometrial biopsy, hysteroscopy, or hysterectomy after the sonographic examination. Clinical and sonographic characteristics were compared between women with diagnoses of cervical or endometrial cancer or hyperplasia (nonbenign group) and women with benign conditions (benign group). Results. The endometrium was significantly thicker in the nonbenign group compared with the benign group (mean ± SD, 9.9 ± 7.4 versus 5.9 ± 4.1 mm; P = .016). None of the patients with adenocarcinoma of the endometrium had endometrial thickness of 3 mm or less, but 2 with endocervical cancer did. Echogenic fluid in the endometrial cavity was significantly more likely to be found in the nonbenign group compared with the benign group (45.8% versus 4.8%; P < .01). Multivariate logistic regression analysis revealed that echogenic fluid in the endometrial cavity was the only significant risk factor for nonbenign conditions (odds ratio, 10.94; 95% confidence interval, 2.67-44.84; P < .01). Conclusions. Postmenopausal women with endometrial fluid collection on sonography should undergo endometrial sampling if the endometrial lining is thicker than 3 mm or the endometrial fluid is echogenic. If the lining is 3 mm or less and the endometrial fluid is clear, endometrial sampling is not necessary, but we recommend endocervical sampling to rule out endocervical cancer.

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