Echocardiographic Epicardial Adipose Tissue Is Related to Anthropometric and Clinical Parameters of Metabolic Syndrome: A New Indicator of Cardiovascular Risk

Gianluca Iacobellis, Maria Cristina Ribaudo, Filippo Assael, Elio Vecci, Claudio Tiberti, Alessandra Zappaterreno, Umberto Di Mario, Frida Leonetti

Research output: Contribution to journalArticle

556 Citations (Scopus)

Abstract

Metabolic syndrome is related to multiple cardiovascular risk factors. Visceral adipose tissue (VAT) plays a key role in metabolic syndrome. Easy detection of VAT could be an important tool to increase knowledge of metabolic syndrome. The objective of this study was to study the relationship of echocardiographic epicardial adipose tissue to anthropometric and clinical parameters of metabolic syndrome. We selected 72 consecutive subjects, 46.5 ± 17.4 yr of age, with a body mass index between 22 and 47 kg/m 2. Each subject underwent transthoracic echocardiogram to measure epicardial fat thickness on right ventricle and magnetic resonance imaging to calculate visceral adipose tissue. Anthropometric, metabolic, and cardiac parameters were also evaluated. Echocardiographic epicardial adipose tissue showed a very good correlation with magnetic resonance imaging abdominal VAT and epicardial fat measurement (Bland-Altman plot and linear regression). Multiple regression analysis showed that waist circumference (r2 = 0.428; P = 0.01), diastolic blood pressure (r2 = 0.387; P = 0.02), and fasting insulin (r2 = 0.387; P = 0.03) were the strongest independent variables correlated with epicardial adipose tissue. Echocardiographic epicardial adipose tissue could be applied as an easy and reliable imaging indicator of VAT and cardiovascular risk.

Original languageEnglish
Pages (from-to)5163-5168
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number11
DOIs
StatePublished - Nov 1 2003
Externally publishedYes

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Intra-Abdominal Fat
Adipose Tissue
Tissue
Fats
Magnetic Resonance Imaging
Blood Pressure
Abdominal Fat
Magnetic resonance
Imaging techniques
Waist Circumference
Heart Ventricles
Linear Models
Fasting
Body Mass Index
Regression Analysis
Insulin
Blood pressure
Linear regression
Regression analysis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Echocardiographic Epicardial Adipose Tissue Is Related to Anthropometric and Clinical Parameters of Metabolic Syndrome : A New Indicator of Cardiovascular Risk. / Iacobellis, Gianluca; Ribaudo, Maria Cristina; Assael, Filippo; Vecci, Elio; Tiberti, Claudio; Zappaterreno, Alessandra; Di Mario, Umberto; Leonetti, Frida.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 11, 01.11.2003, p. 5163-5168.

Research output: Contribution to journalArticle

Iacobellis, Gianluca ; Ribaudo, Maria Cristina ; Assael, Filippo ; Vecci, Elio ; Tiberti, Claudio ; Zappaterreno, Alessandra ; Di Mario, Umberto ; Leonetti, Frida. / Echocardiographic Epicardial Adipose Tissue Is Related to Anthropometric and Clinical Parameters of Metabolic Syndrome : A New Indicator of Cardiovascular Risk. In: Journal of Clinical Endocrinology and Metabolism. 2003 ; Vol. 88, No. 11. pp. 5163-5168.
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