Echocardiographic abnormalities in the mucopolysaccharide storage diseases

Donald M. Gross, Julian C. Williams, Christine Caprioli, Barbara Dominguez, R. Rodney Howell

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


The mucopolysaccharide storage diseases express themselves clinically with a wide variety of abnormalities, including growth and mental retardation, skeletal abnormalities, clouded corneas, nerve compression syndromes, upper airway obstruction and cardiovascular involvement, to name the most common. In most cases the cause of early death is cardiorespiratory failure secondary to cardiovascular involvement and upper airway obstruction. The findings of cardiac ultrasound examination in 29 children, adolescents and young adults are presented. In addition to the previously well-described abnormalities of the mitral and aortic valves in several types of mucopolysaccharide storage disease, we report patchy involvement in some cases, 3 instances of asymmetric septal hypertrophy not previously reported in mucopolysaccharide storage diseases, cardiac involvement in half of our patients with Sanfilippo syndrome and a lack of age-related severity of cardiac involvement even within the specific syndromes.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalThe American Journal of Cardiology
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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