Eccentric iliac artery stenosis: A canine model for angioplasty

Martin Back, George Kopchock, Rodney A. White, Douglas Cavaye, Marwan Tabbara, Shi Kaung Peng

Research output: Contribution to journalArticle

Abstract

A canine model was developed to induce eccentric iliac artery stenosis. Lesions were induced by exposing the medial aspect of the right and left common iliac arteries in four animals to direct argon laser energy (LA). A 2.5-mm diameter side-firing laser probe was used to deliver 10 W of power in 5-s intervals. Twenty-five pulses were delivered over a 5-ctn length of artery with an approximate spot size of 0.8 mm2. Selected arteries (n = 2, LA + Ca) were injected in the same laser injury site with calcium chloride (10% solution). Injections were accurately accomplished using an angioscopically guided guidewire/needle device. In all cases, the internal elastic lamina was broken with focal disruptions of the media. At 9 and 14 days, the LA (n = 3) and LA + Ca vessels (n = 1) had minimal stenoses (< 5% area reduction). These vessels contained edematous media with replacement of necrotic smooth muscle by fibrous tissue. At 23 days, the LA (n = 1) and LA + Ca (n = 1) vessels contained 22% und 33% luminal reductions, respectively, with moderate neointimal proliferation and no evidence of calcification. At 56 days the LA vessels (n = 2) contained 30 and 42% luminal area stenoses with marked neointimal hyperplasia. This preliminary data suggests that controlled arterial wall injury with LA irradiation can induce eccentric fibrointimal lesions in a canine model.

Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalJournal of Investigative Surgery
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Iliac Artery
Angioplasty
Canidae
Pathologic Constriction
Lasers
Arteries
Calcium Chloride
Argon
Wounds and Injuries
Needles
Hyperplasia
Smooth Muscle
Equipment and Supplies
Muscles
Injections

Keywords

  • Argon laser
  • Canine arteriosclerosis
  • Eccentric stenosis
  • Neointimal hyperplasia

ASJC Scopus subject areas

  • Surgery

Cite this

Eccentric iliac artery stenosis : A canine model for angioplasty. / Back, Martin; Kopchock, George; White, Rodney A.; Cavaye, Douglas; Tabbara, Marwan; Peng, Shi Kaung.

In: Journal of Investigative Surgery, Vol. 7, No. 2, 01.01.1994, p. 143-150.

Research output: Contribution to journalArticle

Back, Martin ; Kopchock, George ; White, Rodney A. ; Cavaye, Douglas ; Tabbara, Marwan ; Peng, Shi Kaung. / Eccentric iliac artery stenosis : A canine model for angioplasty. In: Journal of Investigative Surgery. 1994 ; Vol. 7, No. 2. pp. 143-150.
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