Eat-me signals

Keys to molecular phagocyte biology and "Appetite" control

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hundreds of billions of cells undergo apoptosis in our body everyday and are removed by immunologically silent phagocytosis to maintain tissue homeostasis. Impairments in phagocytosis result in autoimmune and/or degenerative diseases. Eat-me signals are the key to the recognition of extracellular cargos and the initiation of the phagocytosis process by activating phagocytic receptors and signaling cascades, and are convenient targets for therapeutic modulation. Despite their importance, eat-me signals and other phagocytosis players are mostly identified on case-by-case basis with daunting challenges. This Commentary focuses on our latest knowledge of the extracellular players, highlights our approaches to systematically map unknown pathways by functional genetic and proteomic technologies, and discusses future direction to unravel the mystery of molecular phagocyte biology.

Original languageEnglish
Pages (from-to)1291-1297
Number of pages7
JournalJournal of Cellular Physiology
Volume227
Issue number4
DOIs
StatePublished - Apr 1 2012

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Tissue homeostasis
Molecular biology
Appetite
Phagocytes
Phagocytosis
Molecular Biology
Modulation
Apoptosis
Proteomics
Homeostasis
Technology
Direction compound

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Eat-me signals : Keys to molecular phagocyte biology and "Appetite" control. / Li, Wei.

In: Journal of Cellular Physiology, Vol. 227, No. 4, 01.04.2012, p. 1291-1297.

Research output: Contribution to journalArticle

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