Early-stage mycosis fungoides variants: Case-based review

Jeong Hee Cho-Vega, Jaime A. Tschen, Madeleine Duvic, Francisco Vega

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. The diagnosis of classic MF is based on a combination of clinical presentation, histopathology, and T-cell monoclonality detected by molecular studies. However, the diagnosis can be difficult in cases of early MF because of the subtle nature of histologic findings and, in cases of variants of MF, because of the unusual clinical and/or pathologic features. In this review, we presented the most frequent variants of MF at early stage including hypopigmented, folliculotropic, pagetoid reticulosis, unilesional, granulomatous, and ichthyosis forms. This case-based clinicopathologic review provides the notion that a comprehensive clinicopathologic correlation is of substantial importance to render the diagnosis of MF. In addition, we discuss the role of molecular studies, which are highly sensitive and recently more applicable to routinely processed skin biopsy specimens in the diagnosis of MF.

Original languageEnglish (US)
Pages (from-to)369-385
Number of pages17
JournalAnnals of Diagnostic Pathology
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2010

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Keywords

  • cutaneous T-cell lymphoma
  • Early stage
  • MF Variants
  • Mycosis fungoides
  • TCR gene rearrangment

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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