Abstract
The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex- and age-matched normal children. The mean (±SD) response related to retinal cellular elements between the photoreceptors and ganglion cells was significantly lower in diabetic children than in the control group (0.38±0.12 vs. 0.51±0.13 μV; unpaired t-test=3;P=0.005). Similarly, ganglion cell function showed a significant impairment in diabetic children with respect to the control group (0.4±0.13 vs. 0.53±0.09 μV; unpaired t-test=5.4;P=0.0001), whereas the photoreceptors appeared unaffected. Metabolic control and disease duration were not correlated with functional deficits. Our results suggest that before puberty, early diabetes may have a selective effect on the neural retina prior to the appearance of microvascular changes. A focal electroretinogram could identify diabetic children with neurosensory disorders who may have a higher risk of developing microvascular retinopathy.
| Original language | English |
|---|---|
| Pages (from-to) | 98-102 |
| Number of pages | 5 |
| Journal | Acta Diabetologica |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 1994 |
| Externally published | Yes |
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Keywords
- Children
- Diabetic retinopathy
- Electroretinogram
- Puberty
- Retinal function
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Early selective neuroretinal disorder in prepubertal type 1 (insulin-dependent) diabetic children without microvascular abnormalities. / Greco, A. V.; Di Leo, M. A S; Caputo, S.; Falsini, B.; Porciatti, Vittorio; Marietti, G.; Ghirlanda, G.
In: Acta Diabetologica, Vol. 31, No. 2, 01.06.1994, p. 98-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early selective neuroretinal disorder in prepubertal type 1 (insulin-dependent) diabetic children without microvascular abnormalities
AU - Greco, A. V.
AU - Di Leo, M. A S
AU - Caputo, S.
AU - Falsini, B.
AU - Porciatti, Vittorio
AU - Marietti, G.
AU - Ghirlanda, G.
PY - 1994/6/1
Y1 - 1994/6/1
N2 - The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex- and age-matched normal children. The mean (±SD) response related to retinal cellular elements between the photoreceptors and ganglion cells was significantly lower in diabetic children than in the control group (0.38±0.12 vs. 0.51±0.13 μV; unpaired t-test=3;P=0.005). Similarly, ganglion cell function showed a significant impairment in diabetic children with respect to the control group (0.4±0.13 vs. 0.53±0.09 μV; unpaired t-test=5.4;P=0.0001), whereas the photoreceptors appeared unaffected. Metabolic control and disease duration were not correlated with functional deficits. Our results suggest that before puberty, early diabetes may have a selective effect on the neural retina prior to the appearance of microvascular changes. A focal electroretinogram could identify diabetic children with neurosensory disorders who may have a higher risk of developing microvascular retinopathy.
AB - The duration of diabetes before puberty is not considered relevant to the future development of complications. To evaluate the effects of diabetes on the neural retina, we analysed macular function by steady-state focal electroretinography in 20 prepubescent diabetic children without vascular retinopathy and in 39 sex- and age-matched normal children. The mean (±SD) response related to retinal cellular elements between the photoreceptors and ganglion cells was significantly lower in diabetic children than in the control group (0.38±0.12 vs. 0.51±0.13 μV; unpaired t-test=3;P=0.005). Similarly, ganglion cell function showed a significant impairment in diabetic children with respect to the control group (0.4±0.13 vs. 0.53±0.09 μV; unpaired t-test=5.4;P=0.0001), whereas the photoreceptors appeared unaffected. Metabolic control and disease duration were not correlated with functional deficits. Our results suggest that before puberty, early diabetes may have a selective effect on the neural retina prior to the appearance of microvascular changes. A focal electroretinogram could identify diabetic children with neurosensory disorders who may have a higher risk of developing microvascular retinopathy.
KW - Children
KW - Diabetic retinopathy
KW - Electroretinogram
KW - Puberty
KW - Retinal function
UR - http://www.scopus.com/inward/record.url?scp=0028290147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028290147&partnerID=8YFLogxK
U2 - 10.1007/BF00570544
DO - 10.1007/BF00570544
M3 - Article
C2 - 7949230
AN - SCOPUS:0028290147
VL - 31
SP - 98
EP - 102
JO - Acta Diabetologica
JF - Acta Diabetologica
SN - 0940-5429
IS - 2
ER -