Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

Joanna J. Wykrzykowska; Michael Rosenzweig; Ronald S. Veazey; Meredith A. Simon; Katherine Halvorsen; Ronald C. Desrosiers; R. Paul Johnson; Andrew A. Lackner

doi:10.1084/jem.187.11.1767

Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

Joanna J. Wykrzykowska, Michael Rosenzweig, Ronald S. Veazey, Meredith A. Simon, Katherine Halvorsen, Ronald C. Desrosiers, R. Paul Johnson, Andrew A. Lackner

Pathology

Research output: Contribution to journal › Article

78 Scopus citations

Abstract

The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4⁺ T cell counts.

Original language	English (US)
Pages (from-to)	1767-1776
Number of pages	10
Journal	Journal of Experimental Medicine
Volume	187
Issue number	11
DOIs	https://doi.org/10.1084/jem.187.11.1767
State	Published - Jun 1 1998

Keywords

AIDS
Animal model
Apoptosis
Pathogenesis
T cell homeostasis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1084/jem.187.11.1767

Fingerprint Dive into the research topics of 'Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus'. Together they form a unique fingerprint.

Cite this

Wykrzykowska, J. J., Rosenzweig, M., Veazey, R. S., Simon, M. A., Halvorsen, K., Desrosiers, R. C., Johnson, R. P., & Lackner, A. A. (1998). Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. Journal of Experimental Medicine, 187(11), 1767-1776. https://doi.org/10.1084/jem.187.11.1767

Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. / Wykrzykowska, Joanna J.; Rosenzweig, Michael; Veazey, Ronald S.; Simon, Meredith A.; Halvorsen, Katherine; Desrosiers, Ronald C.; Johnson, R. Paul; Lackner, Andrew A.

In: Journal of Experimental Medicine, Vol. 187, No. 11, 01.06.1998, p. 1767-1776.

Research output: Contribution to journal › Article

@article{e04de6488b214c3f88cbfee30eff6b35,

title = "Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus",

abstract = "The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.",

keywords = "AIDS, Animal model, Apoptosis, Pathogenesis, T cell homeostasis",

author = "Wykrzykowska, {Joanna J.} and Michael Rosenzweig and Veazey, {Ronald S.} and Simon, {Meredith A.} and Katherine Halvorsen and Desrosiers, {Ronald C.} and Johnson, {R. Paul} and Lackner, {Andrew A.}",

year = "1998",

month = jun,

day = "1",

doi = "10.1084/jem.187.11.1767",

language = "English (US)",

volume = "187",

pages = "1767--1776",

journal = "Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "Rockefeller University Press",

number = "11",

}

TY - JOUR

T1 - Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

AU - Wykrzykowska, Joanna J.

AU - Rosenzweig, Michael

AU - Veazey, Ronald S.

AU - Simon, Meredith A.

AU - Halvorsen, Katherine

AU - Desrosiers, Ronald C.

AU - Johnson, R. Paul

AU - Lackner, Andrew A.

PY - 1998/6/1

Y1 - 1998/6/1

N2 - The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.

AB - The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.

KW - AIDS

KW - Animal model

KW - Apoptosis

KW - Pathogenesis

KW - T cell homeostasis

UR - http://www.scopus.com/inward/record.url?scp=0032101595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032101595&partnerID=8YFLogxK

U2 - 10.1084/jem.187.11.1767

DO - 10.1084/jem.187.11.1767

M3 - Article

C2 - 9607918

AN - SCOPUS:0032101595

VL - 187

SP - 1767

EP - 1776

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 11

ER -