Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

Joanna J. Wykrzykowska; Michael Rosenzweig; Ronald S. Veazey; Meredith A. Simon; Katherine Halvorsen; Ronald C. Desrosiers; R. Paul Johnson; Andrew A. Lackner

doi:10.1084/jem.187.11.1767

Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

Joanna J. Wykrzykowska, Michael Rosenzweig, Ronald S. Veazey, Meredith A. Simon, Katherine Halvorsen, Ronald C. Desrosiers, R. Paul Johnson, Andrew A. Lackner

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4⁺ T cell counts.

Original language	English (US)
Pages (from-to)	1767-1776
Number of pages	10
Journal	Journal of Experimental Medicine
Volume	187
Issue number	11
DOIs	https://doi.org/10.1084/jem.187.11.1767
State	Published - Jun 1 1998
Externally published	Yes

Keywords

AIDS
Animal model
Apoptosis
Pathogenesis
T cell homeostasis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1084/jem.187.11.1767

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Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. / Wykrzykowska, Joanna J.; Rosenzweig, Michael; Veazey, Ronald S.; Simon, Meredith A.; Halvorsen, Katherine; Desrosiers, Ronald C.; Johnson, R. Paul; Lackner, Andrew A.

In: Journal of Experimental Medicine, Vol. 187, No. 11, 01.06.1998, p. 1767-1776.

Research output: Contribution to journal › Article › peer-review

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AU - Simon, Meredith A.

AU - Halvorsen, Katherine

AU - Desrosiers, Ronald C.

AU - Johnson, R. Paul

AU - Lackner, Andrew A.

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AB - The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.

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Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

Abstract

Keywords

ASJC Scopus subject areas

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