Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus

Joanna J. Wykrzykowska, Michael Rosenzweig, Ronald S. Veazey, Meredith A. Simon, Katherine Halvorsen, Ronald C. Desrosiers, R. Paul Johnson, Andrew A. Lackner

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.

Original languageEnglish (US)
Pages (from-to)1767-1776
Number of pages10
JournalJournal of Experimental Medicine
Volume187
Issue number11
DOIs
StatePublished - Jun 1 1998

Keywords

  • AIDS
  • Animal model
  • Apoptosis
  • Pathogenesis
  • T cell homeostasis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Wykrzykowska, J. J., Rosenzweig, M., Veazey, R. S., Simon, M. A., Halvorsen, K., Desrosiers, R. C., Johnson, R. P., & Lackner, A. A. (1998). Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. Journal of Experimental Medicine, 187(11), 1767-1776. https://doi.org/10.1084/jem.187.11.1767