Abstract
The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1767-1776 |
| Number of pages | 10 |
| Journal | Journal of Experimental Medicine |
| Volume | 187 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 1998 |
| Externally published | Yes |
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Keywords
- AIDS
- Animal model
- Apoptosis
- Pathogenesis
- T cell homeostasis
ASJC Scopus subject areas
- Immunology
Cite this
Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. / Wykrzykowska, Joanna J.; Rosenzweig, Michael; Veazey, Ronald S.; Simon, Meredith A.; Halvorsen, Katherine; Desrosiers, Ronald Charles; Johnson, R. Paul; Lackner, Andrew A.
In: Journal of Experimental Medicine, Vol. 187, No. 11, 01.06.1998, p. 1767-1776.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus
AU - Wykrzykowska, Joanna J.
AU - Rosenzweig, Michael
AU - Veazey, Ronald S.
AU - Simon, Meredith A.
AU - Halvorsen, Katherine
AU - Desrosiers, Ronald Charles
AU - Johnson, R. Paul
AU - Lackner, Andrew A.
PY - 1998/6/1
Y1 - 1998/6/1
N2 - The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.
AB - The thymus plays a critical role in the maturation and production of T lymphocytes and is a target oF infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, Followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.
KW - AIDS
KW - Animal model
KW - Apoptosis
KW - Pathogenesis
KW - T cell homeostasis
UR - http://www.scopus.com/inward/record.url?scp=0032101595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032101595&partnerID=8YFLogxK
U2 - 10.1084/jem.187.11.1767
DO - 10.1084/jem.187.11.1767
M3 - Article
VL - 187
SP - 1767
EP - 1776
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 11
ER -