TY - JOUR
T1 - Early post-traumatic cerebral blood flow mapping
T2 - correlation with structural damage after focal injury.
AU - Bullock, R.
AU - Sakas, D.
AU - Patterson, J.
AU - Wyper, D.
AU - Hadley, D.
AU - Maxwell, W.
AU - Teasdale, G. M.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 1992
Y1 - 1992
N2 - Focal post traumatic mass lesions such as contusions and intracerebral haematomas are common, and often difficult for neurosurgeons to manage, because little is known of their pathophysiology. We have mapped cerebral blood flow, and studied small vessel ultrastructure at different time points within the first three weeks of head injury, in patients with these lesions. A zone of ischaemic brain is always present around these lesions, and persists for weeks or months. This accords with astrocyte swelling and microvascular compression seen on electron microscopy. Focal zones of hyperaemia were also present in 42% of patients, within the first two weeks of injury, and this appeared only within apparently normal tissue as judged by late MRI or CT.
AB - Focal post traumatic mass lesions such as contusions and intracerebral haematomas are common, and often difficult for neurosurgeons to manage, because little is known of their pathophysiology. We have mapped cerebral blood flow, and studied small vessel ultrastructure at different time points within the first three weeks of head injury, in patients with these lesions. A zone of ischaemic brain is always present around these lesions, and persists for weeks or months. This accords with astrocyte swelling and microvascular compression seen on electron microscopy. Focal zones of hyperaemia were also present in 42% of patients, within the first two weeks of injury, and this appeared only within apparently normal tissue as judged by late MRI or CT.
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U2 - 10.1007/978-3-7091-9233-7_5
DO - 10.1007/978-3-7091-9233-7_5
M3 - Article
C2 - 1414536
AN - SCOPUS:0026619296
VL - 55
SP - 14
EP - 17
JO - Acta Neurochirurgica, Supplement
JF - Acta Neurochirurgica, Supplement
SN - 0065-1419
ER -