Early nutritional inadequacy is associated with psoas muscle deterioration and worse clinical outcomes in critically ill surgical patients

Daniel Dante Yeh, Luis Alfonso Ortiz-Reyes, Sadeq A. Quraishi, Nalin Chokengarmwong, Laura Avery, Haytham M.A. Kaafarani, Jarone Lee, Peter Fagenholz, Yuchiao Chang, Marc DeMoya, George Velmahos

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Purpose: To explore whether psoas cross sectional area (CSA) and density (Hounsfield Units, HU) are associated with nutritional adequacy and clinical outcomes in surgical intensive care unit patients. Materials and methods: Subjects with at least one CT scan within 72 h of ICU admission were included. Demographic, nutritional, radiographic, and outcomes data were collected. Psoas muscle CSA and HU were assessed at the L4–L5 intervertebral disk level. Change (Δ) in CSA and HU overall and per day were calculated. Results: 140 patients were included. There was no significant correlation between baseline CSA and HU and clinical outcomes. Patients with at least two CT scans (n = 65), had a median decrease in CSA of − 15% [IQR: − 20%, − 8%] and decrease in HU of − 2% [IQR: − 30%, + 24%]. Patients with the greatest daily %HU decline received significantly fewer calories/kg and proteins/kg and accumulated greater protein deficits at day 7 and overall. Patients with daily %HU increase had the shortest ICU and hospital LOS and more ventilator-free days in univariate and multivariable analyses. Conclusions: In this exploratory study, early nutritional deficits were correlated with muscle quality deterioration. Inpatient gain in psoas density, compared to maintenance or loss, is associated with shorter hospital stay.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalJournal of Critical Care
Volume45
DOIs
StatePublished - Jun 2018

Keywords

  • Nutrition
  • Protein
  • Psoas
  • Sarcopenia
  • Surgical

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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