Early life programming and neurodevelopmental disorders

Tracy L. Bale, Tallie Z. Baram, Alan S. Brown, Jill M. Goldstein, Thomas R. Insel, Margaret M. McCarthy, Charles Nemeroff, Teresa M. Reyes, Richard B. Simerly, Ezra S. Susser, Eric J. Nestler

Research output: Contribution to journalArticle

474 Citations (Scopus)

Abstract

For more than a century, clinical investigators have focused on early life as a source of adult psychopathology. Early theories about psychic conflict and toxic parenting have been replaced by more recent formulations of complex interactions of genes and environment. Although the hypothesized mechanisms have evolved, a central notion remains: early life is a period of unique sensitivity during which experience confers enduring effects. The mechanisms for these effects remain almost as much a mystery today as they were a century ago. Recent studies suggest that maternal diet can program offspring growth and metabolic pathways, altering lifelong susceptibility to diabetes and obesity. If maternal psychosocial experience has similar programming effects on the developing offspring, one might expect a comparable contribution to neurodevelopmental disorders, including affective disorders, schizophrenia, autism, and eating disorders. Due to their early onset, prevalence, and chronicity, some of these disorders, such as depression and schizophrenia, are among the highest causes of disability worldwide according to the World Health Organization 2002 report. Consideration of the early life programming and transcriptional regulation in adult exposures supports a critical need to understand epigenetic mechanisms as a critical determinant in disease predisposition. Incorporating the latest insight gained from clinical and epidemiological studies with potential epigenetic mechanisms from basic research, the following review summarizes findings from a workshop on Early Life Programming and Neurodevelopmental Disorders held at the University of Pennsylvania in 2009.

Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalBiological Psychiatry
Volume68
Issue number4
DOIs
StatePublished - Aug 15 2010

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Epigenomics
Schizophrenia
Mothers
Gene-Environment Interaction
Poisons
Autistic Disorder
Metabolic Networks and Pathways
Psychopathology
Mood Disorders
Epidemiologic Studies
Obesity
Research Personnel
Depression
Diet
Education
Neurodevelopmental Disorders
Growth
Research
Clinical Studies
Conflict (Psychology)

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., ... Nestler, E. J. (2010). Early life programming and neurodevelopmental disorders. Biological Psychiatry, 68(4), 314-319. https://doi.org/10.1016/j.biopsych.2010.05.028

Early life programming and neurodevelopmental disorders. / Bale, Tracy L.; Baram, Tallie Z.; Brown, Alan S.; Goldstein, Jill M.; Insel, Thomas R.; McCarthy, Margaret M.; Nemeroff, Charles; Reyes, Teresa M.; Simerly, Richard B.; Susser, Ezra S.; Nestler, Eric J.

In: Biological Psychiatry, Vol. 68, No. 4, 15.08.2010, p. 314-319.

Research output: Contribution to journalArticle

Bale, TL, Baram, TZ, Brown, AS, Goldstein, JM, Insel, TR, McCarthy, MM, Nemeroff, C, Reyes, TM, Simerly, RB, Susser, ES & Nestler, EJ 2010, 'Early life programming and neurodevelopmental disorders', Biological Psychiatry, vol. 68, no. 4, pp. 314-319. https://doi.org/10.1016/j.biopsych.2010.05.028
Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM et al. Early life programming and neurodevelopmental disorders. Biological Psychiatry. 2010 Aug 15;68(4):314-319. https://doi.org/10.1016/j.biopsych.2010.05.028
Bale, Tracy L. ; Baram, Tallie Z. ; Brown, Alan S. ; Goldstein, Jill M. ; Insel, Thomas R. ; McCarthy, Margaret M. ; Nemeroff, Charles ; Reyes, Teresa M. ; Simerly, Richard B. ; Susser, Ezra S. ; Nestler, Eric J. / Early life programming and neurodevelopmental disorders. In: Biological Psychiatry. 2010 ; Vol. 68, No. 4. pp. 314-319.
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