Early events in calcium-induced liposome fusion

Douglas C. Miller, Gerhard P. Dahl

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Calcium-induced interaction of liposomes composed of pure phosphatidylserine (PS) has been studied using a rapid-mixing, rapid-freeze device. Freeze-fracture electron microscopy of this material revealed that liposomes react very rapidly after addition of calcium ions. After only 10 ms (the resolution of the technique) vesicle fusion was apparent. At the same time, however, vesicles also collapsed, and appeared as aggregates of flattened membranes. This may explain controversies which have arisen over vesicle fusion studied with more indirect methods.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalBBA - Biomembranes
Issue number1
StatePublished - Jul 14 1982


  • (Stopped flow/rapid freeze technique)
  • Ca dependence
  • Liposome
  • Membrane fusion
  • Phosphatidylserine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Medicine(all)


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