Early electrophysiologic and anatomic alterations in cat ventricular muscle after coronary artery ligation

M. Nadji, R. J. Myerburg, K. Epstein, A. R. Morales, M. S. Gaide, A. M. Ezrin, S. S. Wong, H. Gelband, A. L. Bassett

Research output: Contribution to journalArticle

2 Scopus citations


(2 figures) The effect of coronary artery ligation on electrophysiologic properties of cat ventricular muscle cells was studied. Depression of resting potential, action potential rate of rise and amplitude was observed in infarcted cells, 30 min to 5 days after ligation. Action potential duration was markedly shortened in acute stages (30-120 min) but gradually lengthened to above control by 48 h. Anatomic sequelae included oedema, loss of fibre striation and cellular necrosis.

Original languageEnglish (US)
Pages (from-to)417-425
Number of pages9
JournalArchives of Physiology and Biochemistry
Issue number5
StatePublished - Jan 1 1981


ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this