Early development of acute myelogenous leukemia following kidney transplantation: Possible role of multiple serum cytokines

George W Burke, Robert Cirocco, Mike Markou, J. Donald Temple, Mustafa Allouch, David Roth, Jose Nery, Joshua Miller

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We report a patient who at the time of kidney transplantation for polycystic kidney disease was found to have an enlarged inguinal lymph node which later demonstrated evidence of extra medullary granulopoiesis. During the first two weeks following kidney transplantation, a striking leukemoid pattern developed and 2 months after transplant the patient was diagnosed with acute myelogenous leukemia (AML). Retrospective analysis of peripheral blood cytokines over this time revealed elevated levels of GMCSF and γIFN at the time of peak peripheral blood WBC with subsequent peaks in IL-4, IL-6 and IL-2 as the peripheral blood WBC fell. A rise in levels of TNFα also preceded the peripheral blood WBC rise (although these concentrations were at or below those following uncomplicated kidney transplants). The clinical course of AML in this patient was marked by relentless relapse despite chemotherapy. The possibility of cytokine facilitated tumor growth is discussed.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalLeukemia and Lymphoma
Volume19
Issue number1-2
DOIs
StatePublished - Jan 1 1995

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Keywords

  • Acute myelogenous leukemia
  • Cyclosporine A
  • Cytokines
  • Gamma interferon
  • GMCSF
  • Intcrlcukin-2R
  • Interleukin-1
  • Interleukin-2
  • Interleukin-3
  • Interleukin-4
  • Interleukin-6
  • Kidney transplantation
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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