Abstract
Background. Microalbuminuria (MA) is an early indicator for glomerulopathy in sickle cell disease (SCD). Procedure. We reviewed the medical records of asymptomatic patients ages 4-20 with sickle hemoglobinopathies, who were screened for MA in order to find out its prevalence and risk factors. Results. Nineteen of 120 (15.8%) screened patients had MA detected by spot urine (mean albumin absolute value 6.95 ± 0.56 mg/dl) and abnormal albumin to creatinine ratios (79.8 ± 0.62 mg/g creatinine). Twenty four-hour urine collections confirmed 57% of MA cases by spot urine. There was no difference in hyperfiltration between positive and negative patients. From the MA-positive patients, 15 had SS (16.8% of SS group) and 4 had SC (18% of SC group). Nineteen percent of children 10 years of age or older had MA, as compared to 8% of the younger children (P = 0.018), demonstrating that increasing age is a risk factor for MA. There was a positive correlation between MA and acute chest syndrome. Young age at start of chronic transfusions was inversely related to MA and therefore renoprotective (P = 0.03). We did not see a protective effect in the group of patients taking hydroxyurea for a relatively short time, mean age at start of treatment 12 ± 5 years; however the sample was small. Conclusions. We conclude that: (1) children with sickle cell hemoglobinopathies 10 years or older should be screened for MA and (2) chronic transfusions starting at an early age may be renoprotective.
| Original language | English |
|---|---|
| Pages (from-to) | 71-76 |
| Number of pages | 6 |
| Journal | Pediatric Blood and Cancer |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2006 |
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Keywords
- Nephrology
- Pediatric hematology/oncology
- Sickle cell disease
ASJC Scopus subject areas
- Cancer Research
- Pediatrics, Perinatology, and Child Health
- Hematology
Cite this
Early blood transfusions protect against microalbuminuria in children with sickle cell disease. / Alvarez, Ofelia A; Montane, Brenda; Lopez, Gabriela; Wilkinson, James; Miller, Tracie L.
In: Pediatric Blood and Cancer, Vol. 47, No. 1, 01.07.2006, p. 71-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early blood transfusions protect against microalbuminuria in children with sickle cell disease
AU - Alvarez, Ofelia A
AU - Montane, Brenda
AU - Lopez, Gabriela
AU - Wilkinson, James
AU - Miller, Tracie L
PY - 2006/7/1
Y1 - 2006/7/1
N2 - Background. Microalbuminuria (MA) is an early indicator for glomerulopathy in sickle cell disease (SCD). Procedure. We reviewed the medical records of asymptomatic patients ages 4-20 with sickle hemoglobinopathies, who were screened for MA in order to find out its prevalence and risk factors. Results. Nineteen of 120 (15.8%) screened patients had MA detected by spot urine (mean albumin absolute value 6.95 ± 0.56 mg/dl) and abnormal albumin to creatinine ratios (79.8 ± 0.62 mg/g creatinine). Twenty four-hour urine collections confirmed 57% of MA cases by spot urine. There was no difference in hyperfiltration between positive and negative patients. From the MA-positive patients, 15 had SS (16.8% of SS group) and 4 had SC (18% of SC group). Nineteen percent of children 10 years of age or older had MA, as compared to 8% of the younger children (P = 0.018), demonstrating that increasing age is a risk factor for MA. There was a positive correlation between MA and acute chest syndrome. Young age at start of chronic transfusions was inversely related to MA and therefore renoprotective (P = 0.03). We did not see a protective effect in the group of patients taking hydroxyurea for a relatively short time, mean age at start of treatment 12 ± 5 years; however the sample was small. Conclusions. We conclude that: (1) children with sickle cell hemoglobinopathies 10 years or older should be screened for MA and (2) chronic transfusions starting at an early age may be renoprotective.
AB - Background. Microalbuminuria (MA) is an early indicator for glomerulopathy in sickle cell disease (SCD). Procedure. We reviewed the medical records of asymptomatic patients ages 4-20 with sickle hemoglobinopathies, who were screened for MA in order to find out its prevalence and risk factors. Results. Nineteen of 120 (15.8%) screened patients had MA detected by spot urine (mean albumin absolute value 6.95 ± 0.56 mg/dl) and abnormal albumin to creatinine ratios (79.8 ± 0.62 mg/g creatinine). Twenty four-hour urine collections confirmed 57% of MA cases by spot urine. There was no difference in hyperfiltration between positive and negative patients. From the MA-positive patients, 15 had SS (16.8% of SS group) and 4 had SC (18% of SC group). Nineteen percent of children 10 years of age or older had MA, as compared to 8% of the younger children (P = 0.018), demonstrating that increasing age is a risk factor for MA. There was a positive correlation between MA and acute chest syndrome. Young age at start of chronic transfusions was inversely related to MA and therefore renoprotective (P = 0.03). We did not see a protective effect in the group of patients taking hydroxyurea for a relatively short time, mean age at start of treatment 12 ± 5 years; however the sample was small. Conclusions. We conclude that: (1) children with sickle cell hemoglobinopathies 10 years or older should be screened for MA and (2) chronic transfusions starting at an early age may be renoprotective.
KW - Nephrology
KW - Pediatric hematology/oncology
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=33646895494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646895494&partnerID=8YFLogxK
U2 - 10.1002/pbc.20645
DO - 10.1002/pbc.20645
M3 - Article
C2 - 16261557
AN - SCOPUS:33646895494
VL - 47
SP - 71
EP - 76
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 1
ER -