Dystrophic cardiac calcinosis in mice: Abnormal myocardial response to freeze-thaw injury

S. R. Brunnert, N. H. Altman

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Dystrophic cardiac calcinosis (DCC) is a frequent finding in DBA/2, C3H and BALB/c mice and its etiology is not known. Previous studies have speculated that myocardial necrosis is involved in the pathogenesis of DCC. In this study, cardiac necrosis was induced in DBA/2, C3H and C57BL/6 mice by freeze-thaw injury through the abdominal diaphragm. Four weeks after freeze-thawing, the mice were sacrificed and the hearts and diaphragms were examined. In response to injury, cardiac mineralization was present only in DBA/2 and C3H mice. The myocardium of C57BL/6 mice (control strain) healed by fibrosis without mineralization, the normal response of the myocardium to injury. Calcified diaphragms also were present at the site of freeze-thaw injury in DBA/2 and C3H mice, which is supportive evidence that a systemic abnormality is involved in the pathogenesis of DCC. The conclusion from this study is that the pathogenesis of DCC in DBA/2 and C3H mice is multifactorial and involves both myocardial necrosis and an abnormal response to injury.

Original languageEnglish (US)
Pages (from-to)616-619
Number of pages4
JournalLaboratory animal science
Volume40
Issue number6
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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