To determine which features of Syndrome X are more common in first-degree relatives of NIDDM patients, we have evaluated 34 relatives from 9 NIDDM families and 22 age-sex and weight matched control subjects with no family history of diabetes. All subjects underwent anthropométrie and BP measures, fasting serum lipids studies and 75g OGGT. NIDDM relatives had higher TG(22 + 8.5 vs.11+>.8mM,p<0 . 001 ) higher VLDL-C(1±0.5 vs.0.52±0.28mM,p<0.01)and lower HDL-C (0.8+0. 17 vs . 1±0.23mM, p<0.01 ) than control subjects. Only male relatives had a higher DBP(83+9 vs 74+6mmHg,p<0.01).Although none of NIDDM relatives had IGT,they had a higher basal insulin (117+50 vs. 65+_23pM,p<0.001)and a higher insulin area under the curve(p<0.001 ) than the control group.The insulin/ glucose ratio was also higher in the relatives (p<0.011at 0,30,60 and 120min of OGTT.In this group there were associations of basal insulin with TG (r=0.63; p<0.01) and with HDL-C (r=-0.75; p<0.001). These data suggest that hyperinsulinemia in association with lipid abnormalities could appear early(before the development of IGT)in first-degree relatives of NIDDM patients fCONDES-LUZ/CONICI T).
|Original language||English (US)|
|State||Published - Dec 1 1996|
ASJC Scopus subject areas
- Molecular Biology