Dysfunction of early-stage visual processing in schizophrenia

P. D. Butler, I. Schechter, V. Zemon, Stephen Schwartz, V. C. Greenstein, J. Gordon, C. E. Schroeder, D. C. Javitt

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

Objective: Schizophrenia is associated with deficits in higher-order processing of visual information. This study evaluated the integrity of early visual processing in order to evaluate the overall pattern of visual dysfunction in schizophrenia. Method: Steady-state visual-evoked potential responses were recorded over the occipital cortex in patients with schizophrenia and in age- and sex-matched comparison volunteers. Visual-evoked potentials were obtained for stimuli composed of isolated squares that were modulated sinusoidally in luminance contrast, number of squares, or chromatic contrast in order to emphasize magnocellular or parvocellular visual pathway activity. Results: Responses of patients to magnocellular-biased stimuli were significantly lower than those of comparison volunteers. These lower response levels were observed in conditions using both low luminance contrast and large squares that biased processing toward the magnocellular pathway. In contrast, responses to stimuli that biased processing toward the parvocellular pathway were not significantly different between schizophrenia patients and comparison volunteers. A significant interaction of group and stimulus type was observed in the condition using low luminance contrast. Conclusions: These findings suggest a dysfunction of lower-level visual pathways, which was more prominent for magnocellular than parvocellular biased stimuli. The magnocellular pathway helps in orienting toward salient stimuli. A magnocellular pathway deficit could contribute to higher-level visual cognitive deficits in schizophrenia.

Original languageEnglish
Pages (from-to)1126-1133
Number of pages8
JournalAmerican Journal of Psychiatry
Volume158
Issue number7
DOIs
StatePublished - Jul 19 2001
Externally publishedYes

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Schizophrenia
Visual Evoked Potentials
Volunteers
Visual Pathways
Occipital Lobe
Automatic Data Processing
Color

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Butler, P. D., Schechter, I., Zemon, V., Schwartz, S., Greenstein, V. C., Gordon, J., ... Javitt, D. C. (2001). Dysfunction of early-stage visual processing in schizophrenia. American Journal of Psychiatry, 158(7), 1126-1133. https://doi.org/10.1176/appi.ajp.158.7.1126

Dysfunction of early-stage visual processing in schizophrenia. / Butler, P. D.; Schechter, I.; Zemon, V.; Schwartz, Stephen; Greenstein, V. C.; Gordon, J.; Schroeder, C. E.; Javitt, D. C.

In: American Journal of Psychiatry, Vol. 158, No. 7, 19.07.2001, p. 1126-1133.

Research output: Contribution to journalArticle

Butler, PD, Schechter, I, Zemon, V, Schwartz, S, Greenstein, VC, Gordon, J, Schroeder, CE & Javitt, DC 2001, 'Dysfunction of early-stage visual processing in schizophrenia', American Journal of Psychiatry, vol. 158, no. 7, pp. 1126-1133. https://doi.org/10.1176/appi.ajp.158.7.1126
Butler PD, Schechter I, Zemon V, Schwartz S, Greenstein VC, Gordon J et al. Dysfunction of early-stage visual processing in schizophrenia. American Journal of Psychiatry. 2001 Jul 19;158(7):1126-1133. https://doi.org/10.1176/appi.ajp.158.7.1126
Butler, P. D. ; Schechter, I. ; Zemon, V. ; Schwartz, Stephen ; Greenstein, V. C. ; Gordon, J. ; Schroeder, C. E. ; Javitt, D. C. / Dysfunction of early-stage visual processing in schizophrenia. In: American Journal of Psychiatry. 2001 ; Vol. 158, No. 7. pp. 1126-1133.
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