Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques

Nichole Klatt, Lauren A. Canary, Thomas H. Vanderford, Carol L. Vinton, Jessica C. Engram, Richard M. Dunham, Heather E. Cronise, Joanna M. Swerczek, Bernard A.P. Lafont, Louis J. Picker, Guido Silvestri, Jason M. Brenchley

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Pigtail macaques (PTM) are an excellent model for HIV research; however, the dynamics of simian immunodeficiency virus (SIV) SIVmac239 infection in PTM have not been fully evaluated. We studied nine PTM prior to infection, during acute and chronic SIVmac239 infections, until progression to AIDS. We found PTM manifest clinical AIDS more rapidly than rhesus macaques (RM), as AIDS-defining events occurred at an average of 42.17 weeks after infection in PTM compared to 69.56 weeks in RM (P=0.0018). However, increased SIV progression was not associated with increased viremia, as both peak and set-point plasma viremias were similar between PTM and RM (P=0.7953 and P=0.1006, respectively). Moreover, this increased disease progression was not associated with rapid CD4 + T cell depletion, as CD4 + T cell decline resembled other SIV/human immunodeficiency virus (HIV) models. Since immune activation is the best predictor of disease progression during HIV infection, we analyzed immune activation by turnover of T cells by BrdU decay and Ki67 expression. We found increased levels of turnover prior to SIV infection of PTM compared to that observed with RM, which may contribute to their increased disease progression rate. These data evaluate the kinetics of SIVmac239-induced disease progression and highlight PTM as a model for HIV infection and the importance of immune activation in SIV disease progression.

Original languageEnglish (US)
Pages (from-to)1203-1213
Number of pages11
JournalJournal of Virology
Volume86
Issue number2
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Macaca nemestrina
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
Macaca
disease course
Disease Progression
Macaca mulatta
infection
HIV
Acquired Immunodeficiency Syndrome
T-lymphocytes
Viremia
viremia
Human immunodeficiency virus
HIV infections
T-Lymphocytes
Infection
Bromodeoxyuridine
deterioration

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Klatt, N., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., ... Brenchley, J. M. (2012). Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. Journal of Virology, 86(2), 1203-1213. https://doi.org/10.1128/JVI.06033-11

Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. / Klatt, Nichole; Canary, Lauren A.; Vanderford, Thomas H.; Vinton, Carol L.; Engram, Jessica C.; Dunham, Richard M.; Cronise, Heather E.; Swerczek, Joanna M.; Lafont, Bernard A.P.; Picker, Louis J.; Silvestri, Guido; Brenchley, Jason M.

In: Journal of Virology, Vol. 86, No. 2, 01.01.2012, p. 1203-1213.

Research output: Contribution to journalArticle

Klatt, N, Canary, LA, Vanderford, TH, Vinton, CL, Engram, JC, Dunham, RM, Cronise, HE, Swerczek, JM, Lafont, BAP, Picker, LJ, Silvestri, G & Brenchley, JM 2012, 'Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques', Journal of Virology, vol. 86, no. 2, pp. 1203-1213. https://doi.org/10.1128/JVI.06033-11
Klatt N, Canary LA, Vanderford TH, Vinton CL, Engram JC, Dunham RM et al. Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. Journal of Virology. 2012 Jan 1;86(2):1203-1213. https://doi.org/10.1128/JVI.06033-11
Klatt, Nichole ; Canary, Lauren A. ; Vanderford, Thomas H. ; Vinton, Carol L. ; Engram, Jessica C. ; Dunham, Richard M. ; Cronise, Heather E. ; Swerczek, Joanna M. ; Lafont, Bernard A.P. ; Picker, Louis J. ; Silvestri, Guido ; Brenchley, Jason M. / Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques. In: Journal of Virology. 2012 ; Vol. 86, No. 2. pp. 1203-1213.
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