Dynamic reciprocity in the wound microenvironment

Gregory S. Schultz, Jeffrey M. Davidson, Robert S. Kirsner, Paul Bornstein, Ira M. Herman

Research output: Contribution to journalReview articlepeer-review

282 Scopus citations


Here, we define dynamic reciprocity (DR) as an ongoing, bidirectional interaction among cells and their surrounding microenvironment. In this review, we posit that DR is especially meaningful during wound healing as the DR-driven biochemical, biophysical, and cellular responses to injury play pivotal roles in regulating tissue regenerative responses. Such cell-extracellular matrix interactions not only guide and regulate cellular morphology, but also cellular differentiation, migration, proliferation, and survival during tissue development, including, e.g., embryogenesis, angiogenesis, as well as during pathologic processes including cancer, diabetes, hypertension, and chronic wound healing. Herein, we examine DR within the wound microenvironment while considering specific examples across acute and chronic wound healing. This review also considers how a number of hypotheses that attempt to explain chronic wound pathophysiology may be understood within the DR framework. The implications of applying the principles of DR to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered.

Original languageEnglish (US)
Pages (from-to)134-148
Number of pages15
JournalWound Repair and Regeneration
Issue number2
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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