Dynamic functional connectivity profile of the salience network across the life span

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The insular cortex and anterior cingulate cortex together comprise the salience or midcingulo-insular network, involved in detecting salient events and initiating control signals to mediate brain network dynamics. The extent to which functional coupling between the salience network and the rest of the brain undergoes changes due to development and aging is at present largely unexplored. Here, we examine dynamic functional connectivity (dFC) of the salience network in a large life span sample (n = 601; 6–85 years old). A sliding-window analysis and k-means clustering revealed five states of dFC formed with the salience network, characterized by either widespread asynchrony or different patterns of synchrony between the salience network and other brain regions. We determined the frequency, dwell time, total transitions, and specific state-to-state transitions for each state and subject, regressing the metrics with subjects' age to identify life span trends. A dynamic state characterized by low connectivity between the salience network and the rest of the brain had a strong positive quadratic relationship between age and both frequency and dwell time. Additional frequency, dwell time, total transitions, and state-to-state transition trends were observed with other salience network states. Our results highlight the metastable dynamics of the salience network and its role in the maturation of brain regions critical for cognition.

Original languageEnglish (US)
Pages (from-to)4740-4749
Number of pages10
JournalHuman Brain Mapping
Volume42
Issue number14
DOIs
StatePublished - Oct 1 2021

Keywords

  • aging
  • brain development
  • brain dynamics
  • flexibility
  • insular cortex
  • metastability
  • midcingulo-insular network

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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