We assessed the incidence and predictors of intracranial hemorrhage (ICH) occurring during ECMO support. Out of 154 patients who received ECMO, 12 (7.8%) developed ICH. Patients with ICH had a longer ECMO duration (10.3 vs. 5.3days, P=0.029), higher activated clotting time (ACT,P=0.027), higher frequency of central ECMO cannulation (P=0.039) and a trend towards higher in-hospital mortality(92% vs. 65%,P=0.091). Multivariate analysis showed that a longer ECMO duration(OR=1.079,95%CI=1.012-1.150,P=0.020) and central ECMO cannulation (OR=5.177,95%CI=1.325-20.220,P=0.018) are independently associated with risk of ICH. We recommend routine neurological checks, monitoring of coagulation parameters and to attempt earlier rather than late weaning from ECMO whenever feasible.
ASJC Scopus subject areas
- Biomedical Engineering