Duration of action of a single, early oral application of chlorhexidine on oral microbial flora in mechanically ventilated patients

A pilot study

Mary Jo Grap, Cindy Munro, R. K. Elswick, Curtis N. Sessler, Kevin R. Ward

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Objective The purpose of this study was to describe the effect of an early post-intubation oral application of chlorhexidine gluconate on oral microbial flora and ventilator-associated pneumonia. Methods Thirty-four intubated patients were randomly assigned to chlorhexidine gluconate by spray or swab or to control group. Oral cultures were done at study admission, 12, 24, 48, and 72 hours, whereas the Clinical Pulmonary Infection Score (CPIS) was documented at study admission, 48, and 72 hours. Results Reductions in oral culture scores (less growth) were only found in the treatment groups (swab and spray); no reduction was found in the control group. There was a trend for fewer positive cultures in the combined treatment groups. The mean CPIS for the control group increased to a level indicating pneumonia (4.7 to 6.6), whereas the CPIS for the treatment group increased only slightly (5.17 to 5.57). Conclusions Trends in the data suggest that use of chlorhexidine gluconate in the early post-intubation period may mitigate or delay the development of ventilator-associated pneumonia.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalHeart and Lung: Journal of Acute and Critical Care
Volume33
Issue number2
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

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Chlorhexidine
Ventilator-Associated Pneumonia
Intubation
Lung
Control Groups
Infection Control
Infection
Pneumonia
Therapeutics
Growth
chlorhexidine gluconate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Duration of action of a single, early oral application of chlorhexidine on oral microbial flora in mechanically ventilated patients : A pilot study. / Grap, Mary Jo; Munro, Cindy; Elswick, R. K.; Sessler, Curtis N.; Ward, Kevin R.

In: Heart and Lung: Journal of Acute and Critical Care, Vol. 33, No. 2, 01.03.2004, p. 83-91.

Research output: Contribution to journalArticle

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AU - Sessler, Curtis N.

AU - Ward, Kevin R.

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AB - Objective The purpose of this study was to describe the effect of an early post-intubation oral application of chlorhexidine gluconate on oral microbial flora and ventilator-associated pneumonia. Methods Thirty-four intubated patients were randomly assigned to chlorhexidine gluconate by spray or swab or to control group. Oral cultures were done at study admission, 12, 24, 48, and 72 hours, whereas the Clinical Pulmonary Infection Score (CPIS) was documented at study admission, 48, and 72 hours. Results Reductions in oral culture scores (less growth) were only found in the treatment groups (swab and spray); no reduction was found in the control group. There was a trend for fewer positive cultures in the combined treatment groups. The mean CPIS for the control group increased to a level indicating pneumonia (4.7 to 6.6), whereas the CPIS for the treatment group increased only slightly (5.17 to 5.57). Conclusions Trends in the data suggest that use of chlorhexidine gluconate in the early post-intubation period may mitigate or delay the development of ventilator-associated pneumonia.

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