Durability of Cryoballoon Ablation in Neoplastic Barrett's Esophagus

Mohamad Dbouk, Malorie Simons, Bingkai Wang, Michael Rosenblum, Olaya I.Brewer Gutierrez, Eun J. Shin, Saowanee Ngamruengphong, Lysandra Voltaggio, Elizabeth Montgomery, Marcia Irene Canto

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND AIMS: Endoscopic ablation can eradicate neoplastic Barrett's esophagus (BE) without visible lesions. Cryoballoon ablation (CBA) is an established but relatively newer ablative technique that can eliminate BE but data on the durability of its treatment effects are lacking. We assessed the durability of CBA treatment for neoplastic BE. METHODS: We performed a single-center cohort study of consecutive BE patients with confirmed low-grade dysplasia, high-grade dysplasia or intramucosal cancer treated with CBA to eradicate all BE. We excluded patients with prior ablative therapy. Visible lesions were removed with endoscopic mucosal resection prior to CBA. Outcomes included complete eradication of dysplasia (CE-D) and complete eradication of intestinal metaplasia (CE-IM) at 1 year, durability at 2 and 3 years after initial ablation, cumulative recurrence rate of dysplasia and IM, and rate of neoplastic progression. RESULTS: Fifty-nine patients (55.9% with high-grade dysplasia; 20.3% with prior endoscopic mucosal resection) were tracked for a median of 54.3 months. CE-D and CE-IM at 1 year were 94.6% (53/56) and 75% (42/56), respectively. Allowing for retreatment, rates of maintained CE-D and CE-IM for those who have achieved CE-D or CE-IM were 100% (53/53) and 98% (47/48) at 2 years; 100% (45/45) and 98% (40/41), at 3 years, respectively. Cumulative recurrence rate was 1.9% (1/53) for dysplasia and 14.6% (7/48) for IM (not allowing for retreatment). There was no neoplastic progression. CONCLUSION: In treatment-naïve patients with dysplastic BE, CBA is a durable endoscopic eradication therapy but endoscopic surveillance after eradication is still warranted.

Original languageEnglish (US)
Pages (from-to)136-144
Number of pages9
JournalTechniques and Innovations in Gastrointestinal Endoscopy
Issue number2
StatePublished - Jan 2022


  • Barrett's esophagus
  • Cryoballoon ablation
  • Cryotherapy
  • Endoscopic eradication therapy, Durability
  • Recurrence rate

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Durability of Cryoballoon Ablation in Neoplastic Barrett's Esophagus'. Together they form a unique fingerprint.

Cite this