Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats

Claudia Emanuelli Ebertz, Maria Lúcia Bonfleur, Iala Milene Bertasso, Mariana Carla Mendes, Camila Lubaczeuski, Cezar de Freitas Araujo Allan, Antônio Marcus Paes, Elaine Manoela Porto de Amorim, Sandra Lucinei Balbo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

METHODS: Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.

PURPOSE: To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).

RESULTS: The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.

CONCLUSION: Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.

Original languageEnglish (US)
Pages (from-to)608-614
Number of pages7
JournalActa Cirurgica Brasileira
Volume29
Issue number9
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Keywords

  • Fatty liver
  • Jejunoileal bypass
  • Obesity
  • Rats

ASJC Scopus subject areas

  • Surgery

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