Duchenne Muscular Dystrophy: Use of Rubidium Chloride Rb 86 in the Detection of Carriers of the Gene

Walter G. Bradley, David Gardner Medwin, John Haggith, John N. Walton, Richard Hesp

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Female carriers of the gene for Duchenne muscular dystrophy have been reported to have a decreased total body potassium concentration and a reduced biological half-life of rubidium chloride Rb 86. We have studied these factors in four “definite” carriers, five normal women, and two normal men. There was no significant difference between the mean values of either factor for the first two groups. The biological half-life of Rb 86 was significantly shorter than in normal women in one carrier, who also has a raised serum creatine phosphokinase activity. These results indicate that neither measurement is likely to be of great value in the detection of carriers of Duchenne muscular dystrophy.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalArchives of neurology
Volume25
Issue number3
DOIs
StatePublished - Sep 1971
Externally publishedYes

Keywords

  • Muscular dystrophy
  • heterozygote
  • potassium
  • rubidium

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Duchenne Muscular Dystrophy: Use of Rubidium Chloride Rb 86 in the Detection of Carriers of the Gene'. Together they form a unique fingerprint.

  • Cite this