Abstract
In 10 K artificial seawater (ASW). D2O replacement reduced the Na efflux of squid axons by about one third. In 0 K ASW, D2O replacement had little effect. D2O reduced the K+ sensitivity of the efllux but increased the affinity for K+. A 4° decrease in temperature mimicked the effects of D2O. When axons were injected with arginine, to decrease the ATP/ADP ratio, they lost K+ sensitivity in normal ASW, as expected. Their efflux into 0 K ASW became D2O sensitive. The results are discussed in terms of conformational changes in the Na pump molecular complex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 277-281 |
| Number of pages | 5 |
| Journal | The Journal of Membrane Biology |
| Volume | 96 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 1 1987 |
Keywords
- deuterium oxide
- heavy water
ASJC Scopus subject areas
- Physiology
- Cell Biology
- Biophysics
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Cite this
Landowne, D. (1987). D2O and the sodium pump in squid nerve membrane. The Journal of Membrane Biology, 96(3), 277-281. https://doi.org/10.1007/BF01869309