DSLINK: A computer program for gene-centromere linkage analysis in families with a trisomic offspring

S. L. Halloran, A. Chakravarti

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.

Original languageEnglish (US)
Pages (from-to)350-355
Number of pages6
JournalAmerican journal of human genetics
Volume41
Issue number3
StatePublished - Dec 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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