DSIP - more than a sleep peptide?

Abba J. Kastin, Gayle A. Olson, Andrew V Schally, David H. Coy

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In several species DSIP at low doses has been shown to promote sleep. Although its physiological role remains to be clarified, DSIP illustrates several concepts applicable to other brain peptides. These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form. Concepts applicable to one neuropeptide, therefore, appear to be applicable to others. In this article Abba Kastin and colleagues review the known effects of DSIP and argue that more work needs to be carried out before it can be labelled functionally.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalTrends in Neurosciences
Volume3
Issue numberC
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Delta Sleep-Inducing Peptide
Sleep
Peptides
Neuropeptides
Blood-Brain Barrier
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

DSIP - more than a sleep peptide? / Kastin, Abba J.; Olson, Gayle A.; Schally, Andrew V; Coy, David H.

In: Trends in Neurosciences, Vol. 3, No. C, 01.01.1980, p. 163-165.

Research output: Contribution to journalArticle

Kastin, Abba J. ; Olson, Gayle A. ; Schally, Andrew V ; Coy, David H. / DSIP - more than a sleep peptide?. In: Trends in Neurosciences. 1980 ; Vol. 3, No. C. pp. 163-165.
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