DsbA is required for stable expression of outer membrane protein YscC and for efficient Yop secretion in Yersinia pestis

Michael W. Jackson, Gregory V. Plano

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The role of the periplasmic disulfide oxidoreductase DsbA in Yop secretion was investigated in Yersinia pestis. A Y. pestis dsbA mutant secreted reduced amounts of the V antigen and Yops and expressed reduced amounts of the full-sized YscC protein. Site-directed mutagenesis of the four cysteine residues present in the YscC protein resulted in defects similar to those found in the dsbA mutant. These results suggest that YscC contains at least one disulfide bond that is essential for the function of this protein in Yop secretion.

Original languageEnglish (US)
Pages (from-to)5126-5130
Number of pages5
JournalJournal of bacteriology
Issue number16
StatePublished - Aug 1 1999


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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