Abstract
Chronic pruritus is a common condition that has a detrimental impact on quality of life. As the molecular pathogenesis of itch is elucidated, novel therapies that disrupt itch pathways are being investigated. Emerging treatments include drugs targeting the neural system, drugs targeting the immune system, antihistamines, bile acid transport inhibitors, and topical drugs that work through a variety of mechanisms such as phosphodiesterase-4 inhibition or targeting of nerve ion channels. Many of these therapies show promising results in the treatment of chronic itch of various etiologies, such as atopic dermatitis, psoriasis, uremic pruritus, and cholestatic pruritus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-344 |
| Number of pages | 10 |
| Journal | Dermatologic Clinics |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2018 |
Keywords
- Atopic dermatitis
- Cholestatic pruritus
- Chronic itch
- Chronic pruritus
- Novel therapies
- Psoriasis
- Uremic pruritus
ASJC Scopus subject areas
- Dermatology
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Cite this
McEwen, M. W., Fite, E. M., Yosipovitch, G., & Patel, T. (2018). Drugs on the Horizon for Chronic Pruritus. Dermatologic Clinics, 36(3), 335-344. https://doi.org/10.1016/j.det.2018.02.016