Drugs on the Horizon for Chronic Pruritus

Matthew W. McEwen, Elizabeth M. Fite, Gil Yosipovitch, Tejesh Patel

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Chronic pruritus is a common condition that has a detrimental impact on quality of life. As the molecular pathogenesis of itch is elucidated, novel therapies that disrupt itch pathways are being investigated. Emerging treatments include drugs targeting the neural system, drugs targeting the immune system, antihistamines, bile acid transport inhibitors, and topical drugs that work through a variety of mechanisms such as phosphodiesterase-4 inhibition or targeting of nerve ion channels. Many of these therapies show promising results in the treatment of chronic itch of various etiologies, such as atopic dermatitis, psoriasis, uremic pruritus, and cholestatic pruritus.

Original languageEnglish (US)
Pages (from-to)335-344
Number of pages10
JournalDermatologic Clinics
Issue number3
StatePublished - Jul 2018


  • Atopic dermatitis
  • Cholestatic pruritus
  • Chronic itch
  • Chronic pruritus
  • Novel therapies
  • Psoriasis
  • Uremic pruritus

ASJC Scopus subject areas

  • Dermatology


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