Drug-induced liver injury in HIV patients

Guy W. Neff, Dushyantha T Jayaweera, Kenneth E. Sherman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The treatment of HIV has improved over the last decade due in part to the success of treatment with combination-therapy drug "cocktails," better referred to as highly active antiretroviral therapy. The safety and efficacy of these regimens is often complicated by the presence of infectious hepatitis and occurrence of drug-induced liver injury. In most patients, these complications manifest as mild laboratory abnormalities and exist without clinical consequence. However, acute and chronic hepatic injury may lead to increased morbidity and mortality. It is essential to identify all potential causes of liver injury to correctly implement steps to alleviate the condition while maintaining optimal control of HIV viremia.

Original languageEnglish
Pages (from-to)430-437
Number of pages8
JournalGastroenterology and Hepatology
Volume2
Issue number6
StatePublished - Jun 1 2006

Fingerprint

Chemical and Drug Induced Liver Injury
HIV
Hepatitis A
Liver
Viremia
Highly Active Antiretroviral Therapy
Wounds and Injuries
Combination Drug Therapy
Morbidity
Safety
Mortality
Therapeutics

Keywords

  • Drug-induced liver injury
  • HAART
  • Hepatotoxicity
  • HIV

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Drug-induced liver injury in HIV patients. / Neff, Guy W.; Jayaweera, Dushyantha T; Sherman, Kenneth E.

In: Gastroenterology and Hepatology, Vol. 2, No. 6, 01.06.2006, p. 430-437.

Research output: Contribution to journalArticle

Neff, GW, Jayaweera, DT & Sherman, KE 2006, 'Drug-induced liver injury in HIV patients', Gastroenterology and Hepatology, vol. 2, no. 6, pp. 430-437.
Neff, Guy W. ; Jayaweera, Dushyantha T ; Sherman, Kenneth E. / Drug-induced liver injury in HIV patients. In: Gastroenterology and Hepatology. 2006 ; Vol. 2, No. 6. pp. 430-437.
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