Abstract
The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significant role in determining the occurrence or degree of leukopenia from these drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-504 |
| Number of pages | 6 |
| Journal | The Journal of Laboratory and Clinical Medicine |
| Volume | 86 |
| Issue number | 3 |
| State | Published - Sep 1975 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine