Drug-induced inhibition of myeloid colony growth: protective effect of colony-stimulating factor

Adel A. Yunis, Mary Ann Gross

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significant role in determining the occurrence or degree of leukopenia from these drugs.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalThe Journal of Laboratory and Clinical Medicine
Volume86
Issue number3
StatePublished - Sep 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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