Abstract
The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significant role in determining the occurrence or degree of leukopenia from these drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-504 |
| Number of pages | 6 |
| Journal | The Journal of laboratory and clinical medicine |
| Volume | 86 |
| Issue number | 3 |
| State | Published - 1975 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
- Pathology and Forensic Medicine
Cite this
Drug-induced inhibition of myeloid colony growth : protective effect of colony-stimulating factor. / Yunis, Adel A; Gross, Mary Ann.
In: The Journal of laboratory and clinical medicine, Vol. 86, No. 3, 1975, p. 499-504.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Drug-induced inhibition of myeloid colony growth
T2 - protective effect of colony-stimulating factor
AU - Yunis, Adel A
AU - Gross, Mary Ann
PY - 1975
Y1 - 1975
N2 - The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significant role in determining the occurrence or degree of leukopenia from these drugs.
AB - The effect of some potentially myelotoxic drugs on the growth of colony-forming cells in mouse marrow in vitro was examined. Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs. The degree of drug-induced inhibition of colony growth was inversely proportional to the concentration of colony-stimulating factor in the medium. It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significant role in determining the occurrence or degree of leukopenia from these drugs.
UR - http://www.scopus.com/inward/record.url?scp=0016714608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016714608&partnerID=8YFLogxK
M3 - Article
C2 - 1151165
AN - SCOPUS:0016714608
VL - 86
SP - 499
EP - 504
JO - Translational Research
JF - Translational Research
SN - 1931-5244
IS - 3
ER -