Drug-induced cholestasis

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Drug-induced cholestasis manifests as an acute self-limiting injury or as a chronic perpetuating injury, resulting in duct loss and cirrhosis. The number of drugs implicated in drug-induced cholestasis grows every year as new drugs are developed and approved. Other agents such as herbals, nutritional supplements, and complementary and alternative medicines are also reported to cause cholestatic liver injury. Recent literature on molecular transporters involved in bile transport has improved our understanding of patterns of drug-induced liver injury and the mechanisms of cholestasis. This article summarizes the probable offending drugs, and the diagnosis and management of drug-induced cholestasis.

Original languageEnglish
Pages (from-to)519-531
Number of pages13
JournalClinics in Liver Disease
Volume17
Issue number4
DOIs
StatePublished - Nov 1 2013

Fingerprint

Cholestasis
Pharmaceutical Preparations
Complementary Therapies
Wounds and Injuries
Chemical and Drug Induced Liver Injury
Bile
Fibrosis
Liver

Keywords

  • Bile duct injury
  • Cholestasis
  • Drugs
  • Liver injury
  • Management

ASJC Scopus subject areas

  • Hepatology

Cite this

Drug-induced cholestasis. / Bhamidimarri, Kalyan R; Schiff, Eugene R.

In: Clinics in Liver Disease, Vol. 17, No. 4, 01.11.2013, p. 519-531.

Research output: Contribution to journalArticle

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