Drug-induced cholestasis

Cynthia Levy, Keith D. Lindor

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Drug-induced cholestasis is a common entity, seen with numerous classes of pharmacological agents. A high index of suspicion is required for the correct diagnosis. Different clinical syndromes may be recognized, with variable degrees of hepatitis in association with cholestasis. The most important aspect of treatment is prompt discontinuation of the offending drug. Several agents have been used for symptomatic relieve of the pruritus associated with cholestasis, including cholestyramine, ursodeoxycholic acid, and opiate antagonists, with limited results. Prognosis is usually good, with few cases of prolonged cholestasis leading to vanishing bile duct syndrome. Liver failure may rarely occur if diagnosis goes unrecognized and the inciting drug is not withdrawn.

Original languageEnglish
Pages (from-to)311-330
Number of pages20
JournalClinics in Liver Disease
Volume7
Issue number2
StatePublished - Jun 1 2003
Externally publishedYes

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Cholestasis
Pharmaceutical Preparations
Opiate Alkaloids
Cholestyramine Resin
Ursodeoxycholic Acid
Liver Failure
Pruritus
Bile Ducts
Hepatitis
Pharmacology
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Levy, C., & Lindor, K. D. (2003). Drug-induced cholestasis. Clinics in Liver Disease, 7(2), 311-330.

Drug-induced cholestasis. / Levy, Cynthia; Lindor, Keith D.

In: Clinics in Liver Disease, Vol. 7, No. 2, 01.06.2003, p. 311-330.

Research output: Contribution to journalArticle

Levy, C & Lindor, KD 2003, 'Drug-induced cholestasis', Clinics in Liver Disease, vol. 7, no. 2, pp. 311-330.
Levy C, Lindor KD. Drug-induced cholestasis. Clinics in Liver Disease. 2003 Jun 1;7(2):311-330.
Levy, Cynthia ; Lindor, Keith D. / Drug-induced cholestasis. In: Clinics in Liver Disease. 2003 ; Vol. 7, No. 2. pp. 311-330.
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