Drug development: Longer-lived proteins

Stephan Kontos, Jeffrey A. Hubbell

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biophysical clearance mechanisms, several of which may decrease the drug's circulation time and efficiency. In this tutorial review, we introduce the concepts of physiological protein clearance from the body, and describe several chemical modification and protein engineering approaches used to improve the life span of administered protein therapeutics.

Original languageEnglish (US)
Pages (from-to)2686-2695
Number of pages10
JournalChemical Society Reviews
Issue number7
StatePublished - Mar 12 2012

ASJC Scopus subject areas

  • Chemistry(all)


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