Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting

Montague Lane, Charles L. Vogel, Julie Ferguson, Steven Krasnow, Joseph L. Saiers, John Hamm, Katherine Salva, Peter H. Wiernik, Christopher P. Holroyde, Stuart Hammill, Kirk Shepard, Terry Plasse

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Dronabinol (Marinol®, Roxane Laboratories, Columbus, OH) and prochlorperazine were tested alone and in combination in a randomized, double-blind, parallel group, multicenter study. Patients were randomized to receive either 1) dronabinol 10 mg every 6 hr plus placebo; 2) placebo plus prochlorperazine 10 mg every 6 hr; or 3) dronabinol and prochlorperazine, each 10 mg every 6 hr. Antiemetic treatment was begun 24 hr prior to and continued for 24 hr after the last dose of chemotherapy; all was given orally. Only 29% of patients in group 3 versus 47% in group 1 and 60% in group 2 experienced nausea after chemotherapy. In addition, the median duration per episode and severity of nausea were significantly less with combination therapy. Vomiting occurred after chemotherapy in 41%, 55%, and 35% of patients in groups 1, 2, and 3, respectively. The median duration per episode of vomiting was 1 min in group 3 versus two in group 1 and four in group 2. Side effects, primarily CNS, were more common in group 1 than in group 2; addition of prochlorperazine to dronabinol appeared to decrease the frequency of dysphoric effects seen with the latter agent. The combination was significantly more effective than was either single agent in controlling chemotherapy-induced nausea and vomiting.

Original languageEnglish (US)
Pages (from-to)352-359
Number of pages8
JournalJournal of Pain and Symptom Management
Volume6
Issue number6
DOIs
StatePublished - Aug 1991

Keywords

  • Antiemetic
  • cannabinoids
  • chemotherapy-induced nausea and vomiting
  • dronabinol
  • tetrahydrocannabinol

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

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  • Cite this

    Lane, M., Vogel, C. L., Ferguson, J., Krasnow, S., Saiers, J. L., Hamm, J., Salva, K., Wiernik, P. H., Holroyde, C. P., Hammill, S., Shepard, K., & Plasse, T. (1991). Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting. Journal of Pain and Symptom Management, 6(6), 352-359. https://doi.org/10.1016/0885-3924(91)90026-Z