Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles

Dimitrios Missirlis, Ryuzo Kawamura, Nicola Tirelli, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic® F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7 wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 °C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics.

Original languageEnglish (US)
Pages (from-to)120-129
Number of pages10
JournalEuropean Journal of Pharmaceutical Sciences
Volume29
Issue number2
DOIs
StatePublished - Oct 1 2006

Keywords

  • Delivery system
  • Hydrophobic interactions
  • Inverse emulsion
  • Photopolymerization
  • Poloxamer

ASJC Scopus subject areas

  • Pharmaceutical Science

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