Doxazosin for the treatment of chronic congestive heart failure: Results of a randomized double-blind and placebo-controlled study

Robert DiBianco, John O. Parker, Simon Chakko, Paul H. Tanser, George Emmanuel, Jang B. Singh, Anthony Marlon

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In this study we evaluated the effects of once-daily administration of oral doxazosin in patients with chronic congestive heart failure (CHF). After a stabilization period of at least 2 weeks with digitalis and diuretics, 73 patients with chronic CHF were randomized to receive additionally either doxazosin or placebo in double-blind fashion. Patients underwent weekly dose adjustments with increasing doses of doxazosin (1, 2, 4, 8, and 16 mg daily) or placebo for 5 weeks, and 67 were evaluated for 12 additional weeks on maximally tolerated doses of blinded study drugs. Treatment groups were evaluated with respect to symptoms of heart failure, indexes of quality of life and left ventricular function, frequency and type of arrhythmia, adverse events, and mortality rates. Doxazosin (11.9 ± 0.9 mg) given once daily produced a favorable trend in the investigators' and patients' assessments of symptomatic change. Doxazosin was associated with a significantly higher level of voluntary submaximal exercise and a favorable trend on left ventricular ejection fraction (increase of 9.8% of the baseline value vs 2.7% with placebo; p = NS). During the 3-month steady-dosing period, patients treated with doxazosin had a significant (p < 0.004) reduction in ventricular arrhythmias and significantly fewer morbid and mortal cardiac events (including episodes of worsening heart failure severe enough to prompt discontinuation of the study, myocardial infarction, and death). Doxazosin was well tolerated, producing no major side effects and only a slightly higher frequency of minor treatment-related side effects compared with placebo (p = NS). These findings suggest that doxazosin, in the dosages tested, may be helpful adjunctive treatment for patients with CHF who remain symptomatic with digitalis and diuretics.

Original languageEnglish (US)
Pages (from-to)372-380
Number of pages9
JournalAmerican Heart Journal
Volume121
Issue number1 PART 2
DOIs
StatePublished - Jan 1991

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    DiBianco, R., Parker, J. O., Chakko, S., Tanser, P. H., Emmanuel, G., Singh, J. B., & Marlon, A. (1991). Doxazosin for the treatment of chronic congestive heart failure: Results of a randomized double-blind and placebo-controlled study. American Heart Journal, 121(1 PART 2), 372-380. https://doi.org/10.1016/0002-8703(91)90875-I