Down's syndrome in adults: Brain metabolism

M. Schwartz, R. Duara, J. Haxby, C. Grady, B. J. White, R. M. Kessler, A. D. Kay, N. R. Cutler, S. I. Rapoport

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51 Scopus citations


The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a 51-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions.

Original languageEnglish
Pages (from-to)781-783
Number of pages3
Issue number4612
StatePublished - Sep 23 1983
Externally publishedYes


ASJC Scopus subject areas

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Cite this

Schwartz, M., Duara, R., Haxby, J., Grady, C., White, B. J., Kessler, R. M., Kay, A. D., Cutler, N. R., & Rapoport, S. I. (1983). Down's syndrome in adults: Brain metabolism. Science, 221(4612), 781-783.