Down's syndrome in adults

Brain metabolism

M. Schwartz, R. Duara, J. Haxby, C. Grady, B. J. White, R. M. Kessler, A. D. Kay, N. R. Cutler, S. I. Rapoport

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a 51-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions.

Original languageEnglish
Pages (from-to)781-783
Number of pages3
JournalScience
Volume221
Issue number4612
DOIs
StatePublished - Sep 23 1983
Externally publishedYes

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Down Syndrome
Brain
Glucose
Fluorine
Deoxyglucose
Frontal Lobe
Positron-Emission Tomography
Young Adult
Healthy Volunteers

ASJC Scopus subject areas

  • General

Cite this

Schwartz, M., Duara, R., Haxby, J., Grady, C., White, B. J., Kessler, R. M., ... Rapoport, S. I. (1983). Down's syndrome in adults: Brain metabolism. Science, 221(4612), 781-783. https://doi.org/10.1126/science.6224294

Down's syndrome in adults : Brain metabolism. / Schwartz, M.; Duara, R.; Haxby, J.; Grady, C.; White, B. J.; Kessler, R. M.; Kay, A. D.; Cutler, N. R.; Rapoport, S. I.

In: Science, Vol. 221, No. 4612, 23.09.1983, p. 781-783.

Research output: Contribution to journalArticle

Schwartz, M, Duara, R, Haxby, J, Grady, C, White, BJ, Kessler, RM, Kay, AD, Cutler, NR & Rapoport, SI 1983, 'Down's syndrome in adults: Brain metabolism', Science, vol. 221, no. 4612, pp. 781-783. https://doi.org/10.1126/science.6224294
Schwartz M, Duara R, Haxby J, Grady C, White BJ, Kessler RM et al. Down's syndrome in adults: Brain metabolism. Science. 1983 Sep 23;221(4612):781-783. https://doi.org/10.1126/science.6224294
Schwartz, M. ; Duara, R. ; Haxby, J. ; Grady, C. ; White, B. J. ; Kessler, R. M. ; Kay, A. D. ; Cutler, N. R. ; Rapoport, S. I. / Down's syndrome in adults : Brain metabolism. In: Science. 1983 ; Vol. 221, No. 4612. pp. 781-783.
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