Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units

Marcos De Lima, Lisa S. St. John, Eric D. Wieder, Ming S. Lee, John McMannis, Safa Karandish, Sergio Giralt, Miroslav Beran, Daniel Couriel, Martin Korbling, Samer Bibawi, Richard Champlin, Krishna V. Komanduri

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The small number of progenitor cells is the major limitation to the use of umbilical cord blood (UCB) for the transplantation of adults. We tested the hypothesis that two units transplanted simultaneously could each contribute to haematopoietic reconstitution. A patient with advanced acute lymphocytic leukaemia received a mismatched, unrelated UCB transplant using units from two donors after conditioning. The recipient achieved a complete remission without graft-versus-host disease. Double chimaerism was documented in several leucocyte subpopulations; both units contributed to haematopoiesis until relapse. Triple chimaerism was present from relapse until death due to leukaemia. This approach may potentially improve UCB transplantation outcome for adults lacking a histocompatible donor.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalBritish Journal of Haematology
Volume119
Issue number3
DOIs
StatePublished - Dec 2 2002
Externally publishedYes

Keywords

  • Acute lymphocytic leukaemia
  • Transplantation
  • Umbilical cord blood

ASJC Scopus subject areas

  • Hematology

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    De Lima, M., St. John, L. S., Wieder, E. D., Lee, M. S., McMannis, J., Karandish, S., Giralt, S., Beran, M., Couriel, D., Korbling, M., Bibawi, S., Champlin, R., & Komanduri, K. V. (2002). Double-chimaerism after transplantation of two human leucocyte antigen mismatched, unrelated cord blood units. British Journal of Haematology, 119(3), 773-776. https://doi.org/10.1046/j.1365-2141.2002.03893.x