"Double carbapenem" and oral fosfomycin for the treatment of complicated urinary tract infections caused by blaNDM-harboring Enterobacteriaceae in kidney transplantation

Rossana Rosa, Susan D. Rudin, Laura J. Rojas, Andrea M. Hujer, Armando Perez-Cardona, Federico Perez, Robert A. Bonomo, Octavio V. Martinez, Lilian Abbo, Jose Camargo Galvis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Infections with carbapenemase-producing carbapenem-resistant Enterobacteriaceae represent an emergent problem worldwide. Treatment of infections caused by New Delhi metallo-beta-lactamase (NDM)-harboring Enterobacteriaceae is particularly challenging as it frequently involves the use of nephrotoxic agents, which is problematic in kidney transplant recipients and non-renal transplant patients with marginal kidney function. We present two cases of urinary tract infections caused by NDM-harboring Enterobacteriaceae successfully treated with a combination of "double carbapenem" and oral fosfomycin.

Original languageEnglish (US)
JournalTransplant Infectious Disease
DOIs
StateAccepted/In press - Jan 1 2017

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Keywords

  • Carbapenem-resistant Enterobacteriaceae
  • Carbapenemase
  • Fosfomycin
  • Kidney transplant
  • NDM

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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